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    DPB3 DNA polymerase epsilon noncatalytic subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852580, updated on 19-Jun-2024

    Summary

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    Gene symbol
    DPB3
    Gene description
    DNA polymerase epsilon noncatalytic subunit
    Primary source
    FungiDB:YBR278W
    Locus tag
    YBR278W
    See related
    SGD:S000000482; AllianceGenome:SGD:S000000482; VEuPathDB:YBR278W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA binding activity; DNA polymerase processivity factor activity; and single-stranded DNA 3'-5' exodeoxyribonuclease activity. Involved in error-prone translesion synthesis and leading strand elongation. Part of epsilon DNA polymerase complex. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DPB3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (760294..760899)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-binding protein RIF1 Neighboring gene tyrosine/serine/threonine protein phosphatase PPS1 Neighboring gene Paf1p Neighboring gene SCF ubiquitin ligase complex subunit SAF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleosome core particle remembers its position through DNA replication and RNA transcription. Schlissel G, et al. Proc Natl Acad Sci U S A, 2019 Oct 8. PMID 31511420, Free PMC Article
    2. Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Araki H, et al. Nucleic Acids Res, 1991 Sep 25. PMID 1923754, Free PMC Article
    3. Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase epsilon in DNA replication and the S/M checkpoint pathway. Dua R, et al. J Biol Chem, 1998 Nov 6. PMID 9792727
    4. Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes. Casari E, et al. Nat Commun, 2021 Aug 6. PMID 34362907, Free PMC Article
    5. Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome. Yuan Z, et al. Nat Commun, 2020 Jun 22. PMID 32572031, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to DNA polymerase processivity factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA polymerase processivity factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA 3'-5' DNA exonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leading strand elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in leading strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase epsilon noncatalytic subunit
    NP_009837.1
    • Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      760294..760899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178626.1 → NP_009837.1  TPA: DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009837.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQS3, P27344
      UniProtKB/TrEMBL
      A0A6A5Q4T6, A6ZLL6, B3LMN5, B5VEM3, C7GMV4, D3UF25, G2W9T1, N1P8N3
      Conserved Domains (1) summary
      COG5247
      Location:12 → 89
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6WJV_3.1
    P27344.2

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