mrc1 claspin [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: mrc1
Gene description: claspin
Locus tag: SPOM_SPAC694.06C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag: SPAC694.06c
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Genomic context

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See mrc1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (4209203..4212388, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results identify S. pombe Mrc1 with major role in mediating efficient replication stalling. Its function is independent of the protein's checkpoint activity, but dependent on a helix-turn-helix DNA-binding domain.
Title: The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.
Results show a novel checkpoint-independent function of Mrc1 which may define early-firing origins among the potential origins scattered on the chromosome.
Title: Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.
Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
Title: Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
Mik1 and Mrc1 have roles in checkpoint regulation of G1/S transcription in response to replicative stress
Title: The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.
These results suggest that interactions of the Swi1-Swi3 complex and Hsk1 kinase with Mrc1 may play a role in cellular responses to stalled replication forks in fission yeast
Title: Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast.
Mrc1 that prevent activation of Cds1 have no effect on its ability to support rid mutant viability, suggesting that Mrc1 has a checkpoint-independent role in maintaining the viability of mutants defective in DNA replication initiation
Title: Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.
S. pombe Tel2 plays important roles in the Mrc1-mediated replication checkpoint as well as in the Cds1-independent regulation of genome integrity.
Title: Tel2 is required for activation of the Mrc1-mediated replication checkpoint.
The N-terminal region of the S. pombe replication checkpoint protein Mrc1 has a helix-loop-helix motif that is predicted to bind to DNA. [mrc1]
Title: DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables 3'-flap-structured DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables D-loop DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables Y-form DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables bubble DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork arrest at mating type locus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork arrest at rDNA repeats	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork arrest at tRNA locus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of replication fork protection complex	ISO Inferred from Sequence Orthology more info