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    lsm4 U6 snRNP-associated protein Lsm4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540475, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lsm4
    Official Full Name
    U6 snRNP-associated protein Lsm4
    Primary source
    PomBase:SPBC30D10.06
    Locus tag
    SPOM_SPBC30D10.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See lsm4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (3086053..3088916, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ER membrane organization protein, HVA22/TB2/DP1 family protein Neighboring gene ncRNA Neighboring gene DNA repair protein Neighboring gene biotin-protein ligase Neighboring gene ncRNA Neighboring gene sepiapterin reductase Neighboring gene chaperone protein Mzm1 Neighboring gene ncRNA Neighboring gene replication fork protection complex subunit Swi3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Hu X, et al. Cell Rep, 2020 Dec 29. PMID 33378677
    2. Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe. Wu D, et al. PLoS One, 2012. PMID 22615807, Free PMC Article
    3. Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast. Páez-Moscoso DJ, et al. Nat Commun, 2018 Feb 8. PMID 29422664, Free PMC Article
    4. Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. Montemayor EJ, et al. RNA, 2020 Oct. PMID 32518066, Free PMC Article
    5. LARP7 family proteins have conserved function in telomerase assembly. Collopy LC, et al. Nat Commun, 2018 Feb 8. PMID 29422501, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to RNA folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables U2 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomerase holoenzyme complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of Lsm2-8 complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of telomerase holoenzyme complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U6 snRNP-associated protein Lsm4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3086053..3088916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355800.2 → NP_001342832.1  U6 snRNP-associated protein Lsm4 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14352
      Conserved Domains (1) summary
      cd01723
      Location:2 → 77
      LSm4; Like-Sm protein 4
    Nucleotide Protein
    Heading Accession and Version

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