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    qua quail [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35058, updated on 19-Jun-2024

    Summary

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    Official Symbol
    quaprovided by FlyBase
    Official Full Name
    quailprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003187
    Locus tag
    Dmel_CG6433
    See related
    AllianceGenome:FB:FBgn0003187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.71; CG6433; Dmel\CG6433; fs(2)A12; Qua
    Summary
    Enables actin binding activity. Involved in imaginal disc-derived wing hair organization. Located in cytoplasm. Colocalizes with actin filament. Is expressed in several structures, including atrium; embryonic/larval lymph gland; extended germ band embryo; gonad; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in nephrotic syndrome type 21. Orthologous to several human genes including AVIL (advillin); VIL1 (villin 1); and VILL (villin like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See qua in Genome Data Viewer
    Location:
    36C10-36C10; 2-53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17486806..17497208, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17486806..17497208, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45715 Neighboring gene uncharacterized protein Neighboring gene mitochondrial translation elongation factor Ts

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila quail, a villin-related protein, bundles actin filaments in apoptotic nurse cells. Matova N, et al. Development, 1999 Dec. PMID 10572041
    2. Wolbachia utilize host actin for efficient maternal transmission in Drosophila melanogaster. Newton IL, et al. PLoS Pathog, 2015 Apr. PMID 25906062, Free PMC Article
    3. Passage of Wolbachia pipientis through mutant drosophila melanogaster induces phenotypic and genomic changes. Newton IL, et al. Appl Environ Microbiol, 2015 Feb. PMID 25452279, Free PMC Article
    4. Capping protein beta is required for actin cytoskeleton organisation and cell migration during Drosophila oogenesis. Ogienko AA, et al. Cell Biol Int, 2013 Feb. PMID 23339103
    5. Apoptosis of nurse cells at the late stages of oogenesis of Drosophila melanogaster. Cavaliere V, et al. Dev Genes Evol, 1998 Apr. PMID 9569352

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian nurse cell to oocyte transport HMP PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quail
    Names
    CG6433-PA
    CG6433-PB
    CG6433-PC
    female sterile(2)A12
    qua-PA
    qua-PB
    qua-PC
    villin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17486806..17497208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165222.2 → NP_724060.1  quail, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23989
      Related
      FBpp0080549
      Conserved Domains (5) summary
      smart00153
      Location:852 → 887
      VHP; Villin headpiece domain
      cd11280
      Location:684 → 775
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:271 → 370
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      smart00262
      Location:419 → 521
      GEL; Gelsolin homology domain
      cl15697
      Location:25 → 152
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. NM_165223.3 → NP_724061.1  quail, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23989, Q540V4, Q8INY7, Q9VJC9
      UniProtKB/TrEMBL
      D0IQH1
      Related
      FBpp0080550
      Conserved Domains (5) summary
      smart00153
      Location:853 → 888
      VHP; Villin headpiece domain
      cd11280
      Location:685 → 776
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:272 → 371
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      smart00262
      Location:420 → 522
      GEL; Gelsolin homology domain
      cl15697
      Location:26 → 153
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    3. NM_001259137.2 → NP_001246066.1  quail, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF69
      Conserved Domains (5) summary
      smart00153
      Location:857 → 892
      VHP; Villin headpiece domain
      cd11280
      Location:689 → 780
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:276 → 375
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      smart00262
      Location:424 → 526
      GEL; Gelsolin homology domain
      cl15697
      Location:26 → 147
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NF69 M9NF69
    Q23989.2 Q23989

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