sn singed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: snprovided by FlyBase
Official Full Name: singedprovided by FlyBase
Primary source: FLYBASE:FBgn0003447
Locus tag: Dmel_CG32858
See related: AllianceGenome:FB:FBgn0003447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15331; CG1536; CG32858; Dmel\CG32858; fascin; Fascin; fs(1)A1057; fs(1)K1421; fs(1)K418; fs(1)K473; fs(1)K743; fs(1)M45; fscn; Fscn; Singed; Sn; SN
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including animal organ development; cuticle pattern formation; and plasma membrane bounded cell projection organization. Located in several cellular components, including actin cytoskeleton; neuron projection; and neuronal cell body. Is expressed in several structures, including embryonic/larval circulatory system; embryonic/larval nervous system; epithelium; extended germ band embryo; and ovary. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 30. Orthologous to human FSCN1 (fascin actin-bundling protein 1) and FSCN2 (fascin actin-bundling protein 2, retinal). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 7D1-7D2; 1-22 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7964024..7986601)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7858057..7880634)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Singed and vinculin play redundant roles in cell migration by regulating F-actin.
Title: Singed and vinculin play redundant roles in cell migration by regulating F-actin.
Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration.
Title: Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration.
Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo.
Title: Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo.
Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.
Title: Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture.
essential for actin bundle initiation and stiffening during embryonic tracheal system development
Title: Fascin, may the Forked be with you.
Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.
Title: Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin.
Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
Title: Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling
Title: Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling.
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
Title: Fascin controls neuronal class-specific dendrite arbor morphology.
The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.
Title: Fascin for cell migration in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0360 (e-PCR)
- UniSTS:18090

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microvillar actin bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: singed

Names: CG32858-PA; CG32858-PB; CG32858-PE; CG32858-PG; fascin; sn-PA; sn-PB; sn-PE; sn-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

7964024..7986601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078521.3 → NP_511076.3 singed, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511076.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24524, Q9W3L8

UniProtKB/TrEMBL

A4V441, Q8SY66

Conserved Domains (2) summary

cd00257
Location:275 → 394

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:33 → 147

Fascin; Fascin domain
NM_167143.3 → NP_727227.1 singed, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727227.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24524, Q9W3L8

UniProtKB/TrEMBL

A4V441, Q8SY66

Related

FBpp0071058

Conserved Domains (2) summary

cd00257
Location:275 → 394

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:33 → 147

Fascin; Fascin domain
NM_167142.3 → NP_727226.1 singed, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727226.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24524, Q9W3L8

UniProtKB/TrEMBL

A4V441, Q8SY66

Related

FBpp0071057

Conserved Domains (2) summary

cd00257
Location:275 → 394

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:33 → 147

Fascin; Fascin domain
NM_001169226.2 → NP_001162697.1 singed, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162697.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24524, Q9W3L8

UniProtKB/TrEMBL

A4V441, Q8SY66

Conserved Domains (2) summary

cd00257
Location:275 → 394

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:33 → 147

Fascin; Fascin domain