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    Nepl21 Neprilysin-like 21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43413, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nepl21provided by FlyBase
    Official Full Name
    Neprilysin-like 21provided by FlyBase
    Primary source
    FLYBASE:FBgn0027578
    Locus tag
    Dmel_CG14526
    See related
    AllianceGenome:FB:FBgn0027578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07188; CG14526; Dmel\CG14526
    Summary
    Predicted to be involved in proteolysis. Located in extracellular region. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl21 in Genome Data Viewer
    Location:
    98F1-98F1; 3-97 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28883693..28886015)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24709415..24711737)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 19 Neighboring gene Neprilysin-like 20 Neighboring gene Darkener of apricot Neighboring gene Dpr-interacting protein gamma Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article
    4. Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. Yasuhara JC, et al. PLoS Genet, 2008 Jan. PMID 18208336, Free PMC Article
    5. Mating induces an immune response and developmental switch in the Drosophila oviduct. Kapelnikov A, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18725632, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 21
    Names
    CG14526-PC
    Nepl21-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28883693..28886015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143389.3 → NP_651646.2  Neprilysin-like 21 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651646.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KML7, Q9Y136
      Conserved Domains (2) summary
      cd08662
      Location:63 → 704
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:57 → 707
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KML7 Q7KML7
    Q9Y136 Q9Y136

    Gene LinkOut

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