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    row relative of woc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36685, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rowprovided by FlyBase
    Official Full Name
    relative of wocprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033998
    Locus tag
    Dmel_CG8092
    See related
    AllianceGenome:FB:FBgn0033998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.194; CG8092; Dmel\CG8092; Row; ROW
    Summary
    Contributes to chromatin binding activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Colocalizes with euchromatin. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral muscle primordium. Used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene implicated in White-Sutton syndrome. Orthologous to several human genes including POGZ (pogo transposable element derived with ZNF domain); ZNF280A (zinc finger protein 280A); and ZNF280B (zinc finger protein 280B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See row in Genome Data Viewer
    Location:
    51E5-51E7; 2-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15206527..15213634, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11094032..11101139, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 51a Neighboring gene Ionotropic receptor 51b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of POGZ Is Associated with Intellectual Disability and Autism Spectrum Disorders. Stessman HAF, et al. Am J Hum Genet, 2016 Mar 3. PMID 26942287, Free PMC Article
    2. The chromatin factor ROW cooperates with BEAF-32 in regulating long-range inducible genes. Herman N, et al. EMBO Rep, 2022 Dec 6. PMID 36245419, Free PMC Article
    3. The zinc-finger proteins WOC and ROW play distinct functions within the HP1c transcription complex. Di Mauro G, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Mar. PMID 32006714
    4. dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes. Kessler R, et al. Nat Commun, 2015 Apr 28. PMID 25916810
    5. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that WOC and ROW play distinct functions within the HP1c complex, supporting a model in which WOC interacts with Dsk2 and recruits it to the complex, while ROW mediates binding of the complex to chromatin.
      Title: The zinc-finger proteins WOC and ROW play distinct functions within the HP1c transcription complex.
    2. knockdown of the POGZ ortholog row confirms that dosage of POGZ, specifically in neurons, is essential for normal learning in a habituation paradigm
      Title: Disruption of POGZ Is Associated with Intellectual Disability and Autism Spectrum Disorders.
    3. HP1c, WOC, and Relative-of-WOC (ROW) regulate a common gene expression program that, in part, is executed in the context of the nervous system.
      Title: Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to chromatin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    relative of woc
    Names
    CG8092-PA
    CG8092-PB
    CG8092-PC
    Relative-of-WOC
    row-PA
    row-PB
    row-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15206527..15213634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137175.4 → NP_611019.2  relative of woc, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611019.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U156
      Related
      FBpp0086533
      Conserved Domains (1) summary
      sd00017
      Location:777 → 798
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001274063.2 → NP_001260992.1  relative of woc, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KER0
      Conserved Domains (1) summary
      sd00017
      Location:777 → 798
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_166081.3 → NP_725441.1  relative of woc, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RL2
      Related
      FBpp0086534
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KER0 A0A0B4KER0
    Q5U156 Q5U156
    Q95RL2 Q95RL2
    Q960P7 Q960P7

    Gene LinkOut

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