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    NT5E-2 Ecto-5'-nucleotidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246458, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NT5E-2provided by FlyBase
    Official Full Name
    Ecto-5'-nucleotidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0050104
    Locus tag
    Dmel_CG30104
    See related
    AllianceGenome:FB:FBgn0050104
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30104; CG4837; Dmel\CG30104; FBgn0050104; NT5E2
    Summary
    Enables 5'-nucleotidase activity. Predicted to be involved in AMP catabolic process. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See NT5E-2 in Genome Data Viewer
    Location:
    54B17-54B17; 2-82 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17485002..17493169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13372507..13380674)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene insensible Neighboring gene uncharacterized protein Neighboring gene veil Neighboring gene uncharacterized protein Neighboring gene narrow

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of ecto-5'-nucleotidases and apyrases in Drosophila melanogaster. Fenckova M, et al. Insect Biochem Mol Biol, 2011 Dec. PMID 21996016
    2. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
    3. Complexities of recapitulating polygenic effects in natural populations: replication of genetic effects on wing shape in artificially selected and wild-caught populations of Drosophila melanogaster. Pelletier K, et al. Genetics, 2023 Jul 6. PMID 36961731, Free PMC Article
    4. Epithelial cells release adenosine to promote local TNF production in response to polarity disruption. Poernbacher I, et al. Nat Commun, 2018 Nov 7. PMID 30405122, Free PMC Article
    5. Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase. Sano Y, et al. Mol Biol Cell, 2005 Jun. PMID 15788564, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 17485978-17490671 mobile_element_type = transposon:F{}842

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ecto-5'-nucleotidase 2
    Names
    CG30104-PA
    CG30104-PB
    NT5E-2-PA
    NT5E-2-PB
    NP_611218.1
    NP_725681.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17485002..17493169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137374.3 → NP_611218.1  Ecto-5'-nucleotidase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZY4
      Related
      FBpp0086084
      Conserved Domains (3) summary
      TIGR01530
      Location:35 → 520
      nadN; NAD pyrophosphatase/5'-nucleotidase NadN
      cd07409
      Location:33 → 320
      MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
      pfam02872
      Location:348 → 519
      5_nucleotid_C; 5'-nucleotidase, C-terminal domain

    2. NM_166232.2 → NP_725681.1  Ecto-5'-nucleotidase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725681.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZY4
      Related
      FBpp0086083
      Conserved Domains (3) summary
      TIGR01530
      Location:35 → 520
      nadN; NAD pyrophosphatase/5'-nucleotidase NadN
      cd07409
      Location:33 → 320
      MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
      pfam02872
      Location:348 → 519
      5_nucleotid_C; 5'-nucleotidase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZY4 Q8SZY4

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