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    CG31183 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41927, updated on 11-Sep-2024

    Summary

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    Official Symbol
    CG31183provided by FlyBase
    Primary source
    FLYBASE:FBgn0051183
    Locus tag
    Dmel_CG31183
    See related
    AllianceGenome:FB:FBgn0051183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11846; CG4224; Dmel\CG31183; DrGC-2; FBgn0038379; GYC; Gyc89A
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; essential hypertension; and myocardial infarction. Orthologous to several human genes including NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    89A6-89A7; 3-58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15857871..15875939, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11683593..11701661, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene crossveinless d Neighboring gene uncharacterized protein Neighboring gene Heavy metal tolerance factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene globin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, characterization, and developmental regulation of a receptor guanylyl cyclase expressed during early stages of Drosophila development. McNeil L, et al. J Biol Chem, 1995 Mar 31. PMID 7706258
    2. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
    3. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. Ayoob JC, et al. J Neurosci, 2004 Jul 28. PMID 15282266, Free PMC Article
    4. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
    5. E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila. Duvall LB, et al. J Biol Rhythms, 2013 Aug. PMID 23929551, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c15872078-15871761 mobile_element_type = transposon:INE-1{}5713

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31183-PA
    CG31183-PB
    guanylyl cyclase at 89A
    NP_001287342.1
    NP_650505.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15857871..15875939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300413.1 → NP_001287342.1  uncharacterized protein Dmel_CG31183, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF17
      Conserved Domains (7) summary
      cd06373
      Location:88 → 498
      PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family
      smart00044
      Location:917 → 1108
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:589 → 883
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:944 → 1130
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:108 → 473
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:893 → 938
      HNOBA; Heme NO binding associated
      pfam07714
      Location:613 → 877
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_142248.3 → NP_650505.2  uncharacterized protein Dmel_CG31183, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650505.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF17
      Related
      FBpp0082641
      Conserved Domains (7) summary
      cd06373
      Location:88 → 498
      PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family
      smart00044
      Location:917 → 1108
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:589 → 883
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:944 → 1130
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:108 → 473
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:893 → 938
      HNOBA; Heme NO binding associated
      pfam07714
      Location:613 → 877
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961R7 Q961R7
    Q9VF17 Q9VF17

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