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    CG10749 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39470, updated on 7-Jul-2024

    Summary

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    Official Symbol
    CG10749provided by FlyBase
    Primary source
    FLYBASE:FBgn0036328
    Locus tag
    Dmel_CG10749
    See related
    AllianceGenome:FB:FBgn0036328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10749
    Summary
    Predicted to enable L-malate dehydrogenase activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in adult head; spermatozoon; and testis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG10749 in Genome Data Viewer
    Location:
    69F2-69F2; 3-39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12972474..12973650)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12965574..12966750)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 69a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Drosophila melanogaster testis transcriptome. Vedelek V, et al. BMC Genomics, 2018 Sep 24. PMID 30249207, Free PMC Article
    2. Genomic signatures of globally enhanced gene duplicate accumulation in the megadiverse higher Diptera fueling intralocus sexual conflict resolution. Bao R, et al. PeerJ, 2020. PMID 33083121, Free PMC Article
    3. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626, Free PMC Article
    4. Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. Bai Y, et al. Genome Biol, 2007. PMID 17233920, Free PMC Article
    5. Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles. Langille MG, et al. Genomics, 2007 Sep. PMID 17628393

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10749-PA
    NP_648616.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12972474..12973650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140359.2 → NP_648616.1  uncharacterized protein Dmel_CG10749 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T412, Q9VU29
      Related
      FBpp0075605
      Conserved Domains (2) summary
      TIGR01772
      Location:29 → 345
      MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
      cd01337
      Location:28 → 337
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T412 Q8T412
    Q9VU29 Q9VU29

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