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    CG4546 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41922, updated on 19-Jun-2024

    Summary

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    Official Symbol
    CG4546provided by FlyBase
    Primary source
    FLYBASE:FBgn0038373
    Locus tag
    Dmel_CG4546
    See related
    AllianceGenome:FB:FBgn0038373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AK-3; Dmel\CG4546; FBgn0038373
    Summary
    Predicted to enable creatine kinase activity. Involved in multicellular organism reproduction. Located in extracellular space. Is expressed in adult head and spermatozoon. Orthologous to several human genes including CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG4546 in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15846534..15848436)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11672256..11674158)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-4911 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) 23 kDa subunit Neighboring gene spindle E Neighboring gene PSEA-binding protein 45kD Neighboring gene crossveinless d Neighboring gene Heavy metal tolerance factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SILAC fly allows for accurate protein quantification in vivo. Sury MD, et al. Mol Cell Proteomics, 2010 Oct. PMID 20525996, Free PMC Article
    2. Functional Diversity and Evolution of the Drosophila Sperm Proteome. Garlovsky MD, et al. Mol Cell Proteomics, 2022 Oct. PMID 35985624, Free PMC Article
    3. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Halfon MS, et al. Genome Res, 2002 Jul. PMID 12097338, Free PMC Article
    4. Proteomic discovery of previously unannotated, rapidly evolving seminal fluid genes in Drosophila. Findlay GD, et al. Genome Res, 2009 May. PMID 19411605, Free PMC Article
    5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4546-PA
    arginine kinase 3
    NP_650501.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15846534..15848436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142244.2 → NP_650501.1  uncharacterized protein Dmel_CG4546 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF23
      Related
      FBpp0082638
      Conserved Domains (1) summary
      cd07932
      Location:89 → 450
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF23 Q9VF23

    Gene LinkOut

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