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    Ndc80 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32316, updated on 10-May-2024

    Summary

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    Official Symbol
    Ndc80provided by FlyBase
    Primary source
    FLYBASE:FBgn0030500
    Locus tag
    Dmel_CG9938
    See related
    AllianceGenome:FB:FBgn0030500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9938; Dmel\CG9938; dmNdc80; dNdc80; hec1; Hec1; NDC80
    Summary
    Involved in mitotic metaphase plate congression. Located in kinetochore. Part of Ndc80 complex. Is expressed in adult heart and organism. Orthologous to human NDC80 (NDC80 kinetochore complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Ndc80 in Genome Data Viewer
    Location:
    12A8-12A8; 1-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13609671..13612062, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13503704..13506095, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44654 Neighboring gene uncharacterized protein Neighboring gene BthD selenoprotein Neighboring gene toothrin Neighboring gene Transport and Golgi organization 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes. Drpic D, et al. Cell Rep, 2015 Oct 20. PMID 26456825, Free PMC Article
    2. Kebab: kinetochore and EB1 associated basic protein that dynamically changes its localisation during Drosophila mitosis. Meireles AM, et al. PLoS One, 2011. PMID 21912673, Free PMC Article
    3. Centromeric nucleosomes induce positive DNA supercoils. Furuyama T, et al. Cell, 2009 Jul 10. PMID 19596238, Free PMC Article
    4. Asymmetric Centromeres Differentially Coordinate with Mitotic Machinery to Ensure Biased Sister Chromatid Segregation in Germline Stem Cells. Ranjan R, et al. Cell Stem Cell, 2019 Nov 7. PMID 31564548, Free PMC Article
    5. Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway. Ye AA, et al. Curr Biol, 2015 Jul 20. PMID 26166783, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ndc80
    Names
    CG9938-PA
    Hec1
    Ndc80-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13609671..13612062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132674.3 → NP_572902.1  Ndc80 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYB1
      Related
      FBpp0073681
      Conserved Domains (1) summary
      pfam03801
      Location:63 → 204
      Ndc80_HEC; HEC/Ndc80p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYB1 Q9VYB1

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