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    CG1227 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40872, updated on 10-May-2024

    Summary

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    Official Symbol
    CG1227provided by FlyBase
    Primary source
    FLYBASE:FBgn0037491
    Locus tag
    Dmel_CG1227
    See related
    AllianceGenome:FB:FBgn0037491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1227; MPSK/PSK; Psk
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of cell size. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human STK16 (serine/threonine kinase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG1227 in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7248151..7249738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3073873..3075460, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nucleolar complex protein 3 Neighboring gene uncharacterized protein Neighboring gene DTW domain containing 2 Neighboring gene Odorant-binding protein 84a Neighboring gene Glucose dehydrogenase Neighboring gene long non-coding RNA:CR44338

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Cully M, et al. Mol Cell Biol, 2010 Jan. PMID 19917724, Free PMC Article
    2. Regulators of cell movement during development and regeneration in Drosophila. Myat MM, et al. Open Biol, 2019 May 31. PMID 31039676, Free PMC Article
    3. The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis. McMillan EA, et al. J Biol Chem, 2018 Feb 23. PMID 29326167, Free PMC Article
    4. RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. Dorer MS, et al. PLoS Pathog, 2006 Apr. PMID 16652170, Free PMC Article
    5. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Yin Z, et al. Nat Cell Biol, 2013 Jul. PMID 23748611, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1227-PA
    CG1227-PB
    NP_001287207.1
    NP_649712.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7248151..7249738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141455.4 → NP_649712.1  uncharacterized protein Dmel_CG1227, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI84
      Related
      FBpp0081116
      Conserved Domains (2) summary
      smart00220
      Location:30 → 300
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13986
      Location:29 → 314
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    2. NM_001300278.1 → NP_001287207.1  uncharacterized protein Dmel_CG1227, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI84
      Conserved Domains (2) summary
      smart00220
      Location:30 → 300
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13986
      Location:29 → 314
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI84 Q9VI84

    Gene LinkOut

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