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    URA10 orotate phosphoribosyltransferase URA10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855313, updated on 29-Jun-2024

    Summary

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    Gene symbol
    URA10
    Gene description
    orotate phosphoribosyltransferase URA10
    Primary source
    FungiDB:YMR271C
    Locus tag
    YMR271C
    See related
    SGD:S000004884; AllianceGenome:SGD:S000004884; VEuPathDB:YMR271C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables orotate phosphoribosyltransferase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleoside biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See URA10 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (806865..807548, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Tma23p Neighboring gene Rrn9p Neighboring gene tRNA-Gln Neighboring gene fatty acid alpha-hydroxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. QM/MM reveals the sequence of substrate binding during OPRT action. Subrahmanyeswara Rao NN, et al. Comput Biol Chem, 2018 Jun. PMID 29533816
    2. Cloning and sequencing of URA10, a second gene encoding orotate phosphoribosyl transferase in Saccharomyces cerevisiae. de Montigny J, et al. Curr Genet, 1990 Feb. PMID 2182197
    3. Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast. Victor J, et al. J Biol Chem, 1979 Apr 25. PMID 218950
    4. The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation. Hohmann S, et al. Curr Genet, 1994 Oct. PMID 7882422
    5. Purification and properties of orotidine-5'-phosphate pyrophosphorylase and orotidine-5'-phosphate decarboxylase from baker's yeast. Umezu K, et al. J Biochem, 1971 Aug. PMID 5094209

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orotate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables orotate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orotate phosphoribosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables orotate phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables orotate phosphoribosyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleobase-containing small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine ribonucleoside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine ribonucleoside biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pyrimidine ribonucleoside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    orotate phosphoribosyltransferase URA10
    NP_013998.1
    • Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      806865..807548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182778.1 → NP_013998.1  TPA: orotate phosphoribosyltransferase URA10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W097, P30402
      UniProtKB/TrEMBL
      A0A6L1A8K7, A6ZMY6, B3LMF8, B5VQ35, C7GR83, C8ZFD6, N1NYS2
      Conserved Domains (1) summary
      TIGR00336
      Location:17 → 202
      pyrE; orotate phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30402.3

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