U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RNF150 ring finger protein 150 [ Homo sapiens (human) ]

    Gene ID: 57484, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RNF150provided by HGNC
    Official Full Name
    ring finger protein 150provided by HGNC
    Primary source
    HGNC:HGNC:23138
    See related
    Ensembl:ENSG00000170153 AllianceGenome:HGNC:23138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in fat (RPKM 9.0), adrenal (RPKM 7.4) and 21 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RNF150 in Genome Data Viewer
    Location:
    4q31.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (140859807..141212900, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (144179641..144532545, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (141780961..142054623, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 9 Neighboring gene uncharacterized LOC124900787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21936 Neighboring gene uncharacterized LOC124900786 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:141677237-141677879 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:141677880-141678521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141746857-141747378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141747379-141747899 Neighboring gene Sharpr-MPRA regulatory region 7410 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:141972205-141972434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15715 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:142141834-142142340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:142142341-142142845 Neighboring gene zinc finger protein 330 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RNF150 suppresses papillary thyroid carcinoma with ASK1 ubiquitination presenting a direct target via inactivating p38 signaling axis. Deng W, et al. Cell Biol Int, 2023 Jul. PMID 36950779
    2. EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population. Ding Y, et al. Int J Chron Obstruct Pulmon Dis, 2015. PMID 25609945, Free PMC Article
    3. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Kim DK, et al. Am J Respir Crit Care Med, 2012 Dec 15. PMID 23144326, Free PMC Article
    4. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Pao KC, et al. Nature, 2018 Apr. PMID 29643511
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rs10007052 in the RNF150 gene is significantly associated with the risk of COPD in Chinese populations of Hainan province.
      Title: EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC125502

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RING finger protein 150

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020724.2 → NP_065775.1  RING finger protein 150 precursor

      See identical proteins and their annotated locations for NP_065775.1

      Status: VALIDATED

      Source sequence(s)
      AB033040, AC093905, AC096733, AK130520
      Consensus CDS
      CCDS34065.1
      UniProtKB/Swiss-Prot
      Q3T1D0, Q6ZNW6, Q9ULK6
      Related
      ENSP00000425840.1, ENST00000515673.7
      Conserved Domains (3) summary
      cd02122
      Location:45 → 193
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:276 → 319
      zf-RING_2; Ring finger domain
      cl11506
      Location:207 → 232
      UPF0233; uncharacterized protein family (UPF0233)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      140859807..141212900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415998.1 → XP_047271954.1  RING finger protein 150 isoform X5

      UniProtKB/TrEMBL
      D6RIE5

    2. XM_011532148.4 → XP_011530450.1  RING finger protein 150 isoform X3

      See identical proteins and their annotated locations for XP_011530450.1

      UniProtKB/Swiss-Prot
      Q9ULK6
      Related
      ENSP00000394581.2, ENST00000420921.6
      Conserved Domains (3) summary
      pfam13639
      Location:135 → 178
      zf-RING_2; Ring finger domain
      cl10459
      Location:20 → 52
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
      cl11506
      Location:66 → 91
      UPF0233; uncharacterized protein family (UPF0233)

    3. XM_017008475.2 → XP_016863964.1  RING finger protein 150 isoform X4

    4. XM_047415996.1 → XP_047271952.1  RING finger protein 150 isoform X2

    5. XM_005263150.6 → XP_005263207.1  RING finger protein 150 isoform X1

      Conserved Domains (3) summary
      cd02122
      Location:45 → 215
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:298 → 341
      zf-RING_2; Ring finger domain
      cl11506
      Location:229 → 254
      UPF0233; uncharacterized protein family (UPF0233)

    6. XM_017008476.1 → XP_016863965.1  RING finger protein 150 isoform X5

      UniProtKB/TrEMBL
      D6RIE5
      Related
      ENSP00000425947.2, ENST00000506101.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      144179641..144532545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350568.1 → XP_054206543.1  RING finger protein 150 isoform X3

    2. XM_054350567.1 → XP_054206542.1  RING finger protein 150 isoform X1

    3. XM_054350569.1 → XP_054206544.1  RING finger protein 150 isoform X4

    4. XM_054350570.1 → XP_054206545.1  RING finger protein 150 isoform X5

      UniProtKB/TrEMBL
      D6RIE5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULK6.2 GenPept UniProtKB/Swiss-Prot:Q9ULK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools