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    PVRIG PVR related immunoglobulin domain containing [ Homo sapiens (human) ]

    Gene ID: 79037, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PVRIGprovided by HGNC
    Official Full Name
    PVR related immunoglobulin domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:32190
    See related
    Ensembl:ENSG00000213413 MIM:617012; AllianceGenome:HGNC:32190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD112R; C7orf15
    Summary
    Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lymph node (RPKM 13.9), spleen (RPKM 12.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PVRIG in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100219248..100221490)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101459061..101461299)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99816871..99819113)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18425 Neighboring gene 60S ribosomal protein L29-like Neighboring gene glypican 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26344 Neighboring gene STAG3 cohesin complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26345 Neighboring gene CASTOR family member 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99844389-99845186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99845985-99846781 Neighboring gene uncharacterized LOC105375426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99866902-99867424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99867949-99868470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18429 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99886514-99886677 Neighboring gene speedy/RINGO cell cycle regulator family member E3 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia. Li J, et al. Haematologica, 2021 Dec 1. PMID 33147937, Free PMC Article
    2. Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer. Yang C, et al. Mod Pathol, 2023 Apr. PMID 36788088
    3. Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. Xu F, et al. Cancer Immunol Immunother, 2017 Oct. PMID 28623459, Free PMC Article
    4. PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function. Whelan S, et al. Cancer Immunol Res, 2019 Feb. PMID 30659054, Free PMC Article
    5. Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Hu S, et al. Structure, 2024 Jul 11. PMID 38626767

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.
      Title: Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.
    2. Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.
      Title: Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.
    3. COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
      Title: COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
    4. Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.
      Title: Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.
    5. PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia.
      Title: PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia.
    6. we demonstrate that PVRIG and PVRL2 are expressed in human cancers and the PVRIG-PVRL2 and TIGIT-PVR pathways are nonredundant inhibitory signaling pathways.
      Title: PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.
    7. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells.
      Title: Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions.
    8. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals.
      Title: Identification of CD112R as a novel checkpoint for human T cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2463, MGC104322, MGC138295, MGC138297

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein PVRIG
    Names
    CD112 receptor
    nectin-2 receptor
    poliovirus receptor related immunoglobulin domain containing
    poliovirus receptor-related immunoglobulin domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387134.1 → NP_001374063.1  transmembrane protein PVRIG isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC005071
      Conserved Domains (2) summary
      cd00096
      Location:23 → 26
      Ig; Ig strand A [structural motif]
      cl11960
      Location:23 → 125
      Ig; Immunoglobulin domain

    2. NM_001397246.1 → NP_001384175.1  transmembrane protein PVRIG isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC005071
      Consensus CDS
      CCDS94154.1
      UniProtKB/TrEMBL
      A0A8V8TN58
      Related
      ENSP00000514123.1, ENST00000699088.1
      Conserved Domains (1) summary
      PHA03247
      Location:64 → 304
      PHA03247; large tegument protein UL36; Provisional

    3. NM_024070.3 → NP_076975.2  transmembrane protein PVRIG isoform 1

      See identical proteins and their annotated locations for NP_076975.2

      Status: VALIDATED

      Source sequence(s)
      AC005071, BC073861
      Consensus CDS
      CCDS5690.1
      UniProtKB/Swiss-Prot
      D6W5U9, Q6DKI7, Q9BVK3
      Related
      ENSP00000316675.2, ENST00000317271.3
      Conserved Domains (2) summary
      cl11960
      Location:57 → 145
      Ig; Immunoglobulin domain
      cl26464
      Location:84 → 324
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100219248..100221490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101459061..101461299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DKI7.1 GenPept UniProtKB/Swiss-Prot:Q6DKI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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