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    MPP2 MAGUK p55 scaffold protein 2 [ Homo sapiens (human) ]

    Gene ID: 4355, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MPP2provided by HGNC
    Official Full Name
    MAGUK p55 scaffold protein 2provided by HGNC
    Primary source
    HGNC:HGNC:7220
    See related
    Ensembl:ENSG00000108852 MIM:600723; AllianceGenome:HGNC:7220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLG2
    Summary
    Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 9.3), testis (RPKM 5.8) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MPP2 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43875360..43909711, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44727944..44762256, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41952728..41987079, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene CD300 molecule like family member g Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41943686-41943858 Neighboring gene Sharpr-MPRA regulatory region 5434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959115-41959616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959617-41960116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41991041-41991541 Neighboring gene uncharacterized LOC105371787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41994398-41995219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41995220-41996040 Neighboring gene uncharacterized LOC107985086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41997678-41998178 Neighboring gene family with sequence similarity 215 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A. Mazoyer S, et al. Genomics, 1995 Jul 1. PMID 7590743
    2. A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing. Liu X, et al. Cell Mol Immunol, 2023 Nov. PMID 37828081, Free PMC Article
    3. Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21. Smith SA, et al. Genomics, 1996 Jan 15. PMID 8824795
    4. The PDZ protein MPP2 interacts with c-Src in epithelial cells. Baumgartner M, et al. Exp Cell Res, 2009 Oct 15. PMID 19665017
    5. The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons. Pinatel D, et al. J Cell Sci, 2017 Jul 1. PMID 28533267

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing.
      Title: A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing.
    2. MPP2 interacts with c-Src in cells to control c-Src activity and morphological function.
      Title: The PDZ protein MPP2 interacts with c-Src in epithelial cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2, MPP2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686J2189, DKFZp761D0712, DKFZp686A06252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 2
    Names
    discs large, homolog 2
    membrane palmitoylated protein 2
    membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278370.2 → NP_001265299.1  MAGUK p55 subfamily member 2 isoform 1

      See identical proteins and their annotated locations for NP_001265299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC007993, AK295858, AL136554, DC321822
      Consensus CDS
      CCDS62210.1
      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      UniProtKB/TrEMBL
      A0A0C4DH75
      Related
      ENSP00000428182.1, ENST00000518766.5
      Conserved Domains (6) summary
      smart00569
      Location:58 → 111
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:274 → 332
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:404 → 585
      GuKc; Guanylate kinase homologues
      cd00992
      Location:183 → 261
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:394 → 584
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:113 → 164
      L27; L27 domain

    2. NM_001278371.2 → NP_001265300.1  MAGUK p55 subfamily member 2 isoform 2

      See identical proteins and their annotated locations for NP_001265300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
      Source sequence(s)
      AC007993, AK295858, AL136554, DC321822, DC333563
      Consensus CDS
      CCDS62207.1
      UniProtKB/TrEMBL
      B4DRL7, B4DZ84
      Related
      ENSP00000480071.1, ENST00000622681.4
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:218 → 276
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:348 → 529
      GuKc; Guanylate kinase homologues
      cd00992
      Location:127 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain

    3. NM_001278372.2 → NP_001265301.1  MAGUK p55 subfamily member 2 isoform 4

      See identical proteins and their annotated locations for NP_001265301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate coding exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC007993, AK299286, AL136554, X82895
      Consensus CDS
      CCDS62209.1
      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      UniProtKB/TrEMBL
      D3DX49
      Related
      ENSP00000428286.1, ENST00000461854.5
      Conserved Domains (6) summary
      smart00569
      Location:13 → 90
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:253 → 311
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:383 → 564
      GuKc; Guanylate kinase homologues
      cd00992
      Location:162 → 240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:373 → 563
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:92 → 143
      L27; L27 domain

    4. NM_001278373.2 → NP_001265302.1  MAGUK p55 subfamily member 2 isoform 2

      See identical proteins and their annotated locations for NP_001265302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
      Source sequence(s)
      AC007993, AK299286, AL136554
      Consensus CDS
      CCDS62207.1
      UniProtKB/TrEMBL
      B4DRL7, B4DZ84
      Related
      ENSP00000430540.1, ENST00000523501.5
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:218 → 276
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:348 → 529
      GuKc; Guanylate kinase homologues
      cd00992
      Location:127 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain

    5. NM_001278374.2 → NP_001265303.1  MAGUK p55 subfamily member 2 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame coding exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 6 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC007993, AK294564, AL136554
      Consensus CDS
      CCDS62206.1
      UniProtKB/TrEMBL
      B4DS08
      Related
      ENSP00000428136.1, ENST00000520305.5
      Conserved Domains (4) summary
      cd12037
      Location:90 → 148
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:220 → 401
      GuKc; Guanylate kinase homologues
      cd00992
      Location:1 → 77
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:210 → 400
      Guanylate_kin; Guanylate kinase

    6. NM_001278375.2 → NP_001265304.1  MAGUK p55 subfamily member 2 isoform 2

      See identical proteins and their annotated locations for NP_001265304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
      Source sequence(s)
      AC007993, AK302793, AL136554
      Consensus CDS
      CCDS62207.1
      UniProtKB/TrEMBL
      B4DRL7, B4DZ84
      Related
      ENSP00000438012.1, ENST00000536246.5
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:218 → 276
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:348 → 529
      GuKc; Guanylate kinase homologues
      cd00992
      Location:127 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:57 → 108
      L27; L27 domain

    7. NM_001278376.3 → NP_001265305.2  MAGUK p55 subfamily member 2 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 8 which has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AC007993, AK299321, AL136554, DC347918
      Consensus CDS
      CCDS62208.1
      UniProtKB/TrEMBL
      A0A0A0MRU0, B4DRL7
      Related
      ENSP00000366389.3, ENST00000377184.7
      Conserved Domains (5) summary
      smart00569
      Location:30 → 83
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:246 → 304
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:376 → 557
      GuKc; Guanylate kinase homologues
      cd00992
      Location:155 → 233
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:85 → 136
      L27; L27 domain

    8. NM_001278381.2 → NP_001265310.1  MAGUK p55 subfamily member 2 isoform 3

      See identical proteins and their annotated locations for NP_001265310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 3 and 9 encode isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC007993, AK299286, AL136554, DC399913
      Consensus CDS
      CCDS11471.1
      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      UniProtKB/TrEMBL
      D3DX48
      Related
      ENSP00000478528.1, ENST00000612133.4
      Conserved Domains (5) summary
      smart00569
      Location:13 → 66
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:229 → 287
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:359 → 540
      GuKc; Guanylate kinase homologues
      cd00992
      Location:138 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68 → 119
      L27; L27 domain

    9. NM_005374.5 → NP_005365.4  MAGUK p55 subfamily member 2 isoform 3

      See identical proteins and their annotated locations for NP_005365.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 3 and 9 encode isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC007993, AK223560, AK299286, AL136554
      Consensus CDS
      CCDS11471.1
      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      UniProtKB/TrEMBL
      D3DX48
      Related
      ENSP00000269095.4, ENST00000269095.9
      Conserved Domains (5) summary
      smart00569
      Location:13 → 66
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:229 → 287
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:359 → 540
      GuKc; Guanylate kinase homologues
      cd00992
      Location:138 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68 → 119
      L27; L27 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43875360..43909711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450762.2 → XP_024306530.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      UniProtKB/TrEMBL
      D3DX48
      Conserved Domains (5) summary
      smart00569
      Location:13 → 66
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:229 → 287
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:359 → 540
      GuKc; Guanylate kinase homologues
      cd00992
      Location:138 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68 → 119
      L27; L27 domain

    2. XM_011524827.3 → XP_011523129.2  MAGUK p55 subfamily member 2 isoform X5

      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2

    3. XM_024450760.2 → XP_024306528.1  MAGUK p55 subfamily member 2 isoform X1

      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      Conserved Domains (5) summary
      smart00569
      Location:67 → 120
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:283 → 341
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:413 → 594
      GuKc; Guanylate kinase homologues
      cd00992
      Location:192 → 270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:122 → 173
      L27; L27 domain

    4. XM_024450763.2 → XP_024306531.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/Swiss-Prot
      B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
      UniProtKB/TrEMBL
      D3DX48
      Conserved Domains (5) summary
      smart00569
      Location:13 → 66
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:229 → 287
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:359 → 540
      GuKc; Guanylate kinase homologues
      cd00992
      Location:138 → 216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68 → 119
      L27; L27 domain

    5. XM_047436096.1 → XP_047292052.1  MAGUK p55 subfamily member 2 isoform X4

    6. XM_047436095.1 → XP_047292051.1  MAGUK p55 subfamily member 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44727944..44762256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316178.1 → XP_054172153.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/TrEMBL
      D3DX48

    2. XM_054316180.1 → XP_054172155.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/TrEMBL
      D3DX48

    3. XM_054316183.1 → XP_054172158.1  MAGUK p55 subfamily member 2 isoform X5

    4. XM_054316177.1 → XP_054172152.1  MAGUK p55 subfamily member 2 isoform X1

    5. XM_054316179.1 → XP_054172154.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/TrEMBL
      D3DX48

    6. XM_054316182.1 → XP_054172157.1  MAGUK p55 subfamily member 2 isoform X4

    7. XM_054316181.1 → XP_054172156.1  MAGUK p55 subfamily member 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14168.3 GenPept UniProtKB/Swiss-Prot:Q14168

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