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    Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 20527, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Slc2a3provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 3provided by MGI
    Primary source
    MGI:MGI:95757
    See related
    Ensembl:ENSMUSG00000003153 AllianceGenome:MGI:95757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glut3; Glut-3
    Summary
    Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in D-glucose transmembrane transport and dehydroascorbic acid transport. Located in acrosomal membrane and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; early conceptus; and genitourinary system. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 213.3), placenta adult (RPKM 31.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc2a3 in Genome Data Viewer
    Location:
    6 F2; 6 57.82 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122704783..122779149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122727809..122802363, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Nanog 5' regulatory region Neighboring gene predicted pseudogene 10224 Neighboring gene Nanog homeobox Neighboring gene Nanog +60 enhancer Neighboring gene uridine-cytidine kinase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3679 Neighboring gene STARR-positive B cell enhancer ABC_E283 Neighboring gene predicted gene 5112 Neighboring gene forkhead box J2 Neighboring gene microRNA 7231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos. Nagamatsu S, et al. Biochem J, 1994 May 15. PMID 8198523, Free PMC Article
    2. Glucose Transporter 3 is Essential for the Survival of Breast Cancer Cells in the Brain. Kuo MH, et al. Cells, 2019 Dec 4. PMID 31817208, Free PMC Article
    3. Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3. Zhu J, et al. Cell Mol Neurobiol, 2020 Aug. PMID 31884568, Free PMC Article
    4. CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3. Fu C, et al. Cancer Sci, 2021 Mar. PMID 33368883, Free PMC Article
    5. Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders. Shin BC, et al. Exp Neurol, 2021 Apr. PMID 33482226, Free PMC Article

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
      Title: LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
    2. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
      Title: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
    3. Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
      Title: Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
    4. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
      Title: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
    5. Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
      Title: Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
    6. Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
      Title: Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
    7. Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
      Title: Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
    8. High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
      Title: High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
    9. CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
      Title: CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
    10. Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
      Title: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-glucose binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dehydroascorbic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dehydroascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables fructose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables galactose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables galactoside binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xylose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within D-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dehydroascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dehydroascorbic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dehydroascorbic acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in fructose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in galactose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monosaccharide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 3
    Names
    glucose transporter type 3, brain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410371.1 → NP_001397300.1  solute carrier family 2, facilitated glucose transporter member 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC131715

    2. NM_001410372.1 → NP_001397301.1  solute carrier family 2, facilitated glucose transporter member 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC131715, AC163108

    3. NM_001410374.1 → NP_001397303.1  solute carrier family 2, facilitated glucose transporter member 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC131715, AC163108

    4. NM_001410375.1 → NP_001397304.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC131715, AC163108

    5. NM_001410376.1 → NP_001397305.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC131715, AC163108

    6. NM_001410377.1 → NP_001397306.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC131715, AC163108

    7. NM_001410378.1 → NP_001397307.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC131715, AC163108

    8. NM_011401.5 → NP_035531.3  solute carrier family 2, facilitated glucose transporter member 3 isoform b

      See identical proteins and their annotated locations for NP_035531.3

      Status: VALIDATED

      Source sequence(s)
      AC131715
      Consensus CDS
      CCDS20502.1
      UniProtKB/Swiss-Prot
      P32037
      UniProtKB/TrEMBL
      Q3TPL8, Q4FJP8, Q8BLF7
      Related
      ENSMUSP00000032476.5, ENSMUST00000032476.11
      Conserved Domains (2) summary
      cd06174
      Location:14 → 437
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:13 → 465
      Sugar_tr; Sugar (and other) transporter

    RNA

    1. NR_177063.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131715

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122704783..122779149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165983.1 → XP_036021876.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

      UniProtKB/TrEMBL
      Q4FJP8, Q8BLF7
      Conserved Domains (1) summary
      cd17431
      Location:14 → 458
      MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32037.1 GenPept UniProtKB/Swiss-Prot:P32037

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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