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    USP36 ubiquitin specific peptidase 36 [ Homo sapiens (human) ]

    Gene ID: 57602, updated on 28-Oct-2024

    Summary

    Official Symbol
    USP36provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 36provided by HGNC
    Primary source
    HGNC:HGNC:20062
    See related
    Ensembl:ENSG00000055483 MIM:612543; AllianceGenome:HGNC:20062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUB1
    Summary
    This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See USP36 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78787381..78841439, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79682181..79736241, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76783463..76837521, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904066 Neighboring gene MPRA-validated peak3019 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76662364-76662975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76662976-76663586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76663587-76664197 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:76664198-76664807 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76671141-76672019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76672283-76672784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76672785-76673284 Neighboring gene cytohesin 1 Neighboring gene RNA, U6 small nuclear 638, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76719667-76720172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12905 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76770651-76771152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9073 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5512 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76834350-76834864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76834865-76835379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12913 Neighboring gene uncharacterized LOC124904067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9075 Neighboring gene MPRA-validated peak3020 silencer Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene ribosomal protein L9 pseudogene 29 Neighboring gene TIMP metallopeptidase inhibitor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2B deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleolus organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitophagy HMP PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of rRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 36
    Names
    deubiquitinating enzyme 36
    ubiquitin specific protease 36
    ubiquitin thioesterase 36
    ubiquitin-specific-processing protease 36
    NP_001308220.1
    NP_001372098.1
    NP_001372099.1
    NP_001372100.1
    NP_001372101.1
    NP_001372102.1
    NP_001372103.1
    NP_001372104.1
    NP_001372105.1
    NP_001372106.1
    NP_001372107.1
    NP_001372108.1
    NP_001372109.1
    XP_011523367.1
    XP_011523368.1
    XP_011523370.1
    XP_011523371.1
    XP_011523373.1
    XP_016880390.1
    XP_024306613.1
    XP_024306614.1
    XP_047292424.1
    XP_047292425.1
    XP_047292426.1
    XP_047292427.1
    XP_047292428.1
    XP_047292429.1
    XP_047292430.1
    XP_047292431.1
    XP_047292432.1
    XP_054172735.1
    XP_054172736.1
    XP_054172737.1
    XP_054172738.1
    XP_054172739.1
    XP_054172740.1
    XP_054172741.1
    XP_054172742.1
    XP_054172743.1
    XP_054172744.1
    XP_054172745.1
    XP_054172746.1
    XP_054172747.1
    XP_054172748.1
    XP_054172749.1
    XP_054172750.1
    XP_054172751.1
    XP_054172752.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321291.2NP_001308220.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 3-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Related
      ENSP00000441214.1, ENST00000542802.7
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    2. NM_001385169.1NP_001372098.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    3. NM_001385170.1NP_001372099.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 2 and 4-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    4. NM_001385171.1NP_001372100.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, and 5-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    5. NM_001385172.1NP_001372101.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 2-4 and 6-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    6. NM_001385173.1NP_001372102.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 2-5 and 7-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    7. NM_001385174.1NP_001372103.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 2-6, 8, and 9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Related
      ENSP00000401119.4, ENST00000449938.7
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    8. NM_001385175.1NP_001372104.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 2-7 and 9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Related
      ENSP00000465698.2, ENST00000592231.6
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    9. NM_001385176.1NP_001372105.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 2-8, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    10. NM_001385177.1NP_001372106.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:341675
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:1256
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    11. NM_001385178.1NP_001372107.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:341675
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:1256
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    12. NM_001385179.1NP_001372108.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:296630
      PHA03247; large tegument protein UL36; Provisional
      cl02553
      Location:21211
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    13. NM_001385180.1NP_001372109.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022966
      UniProtKB/TrEMBL
      B3KMW2
      Conserved Domains (2) summary
      PHA03247
      Location:287621
      PHA03247; large tegument protein UL36; Provisional
      cl02553
      Location:1202
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RNA

    1. NR_169581.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966
    2. NR_169582.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966
    3. NR_169583.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966
    4. NR_169584.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966
    5. NR_169585.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966
      Related
      ENST00000693020.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78787381..78841439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525071.4XP_011523373.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X10

      Conserved Domains (2) summary
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:122420
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_011525069.4XP_011523371.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

      Conserved Domains (2) summary
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:122420
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. XM_011525066.4XP_011523368.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      See identical proteins and their annotated locations for XP_011523368.1

      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    4. XM_011525065.3XP_011523367.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      See identical proteins and their annotated locations for XP_011523367.1

      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    5. XM_047436472.1XP_047292428.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

    6. XM_047436470.1XP_047292426.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    7. XM_047436469.1XP_047292425.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    8. XM_024450845.2XP_024306613.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    9. XM_024450846.2XP_024306614.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:506840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    10. XM_047436468.1XP_047292424.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    11. XM_011525068.2XP_011523370.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

      Conserved Domains (2) summary
      cd02661
      Location:1256
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1255
      UCH; Ubiquitin carboxyl-terminal hydrolase
    12. XM_017024901.2XP_016880390.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

    13. XM_047436473.1XP_047292429.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    14. XM_047436474.1XP_047292430.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X8

    15. XM_047436475.1XP_047292431.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X9

    16. XM_047436471.1XP_047292427.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

    17. XM_047436476.1XP_047292432.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X11

      UniProtKB/TrEMBL
      A0A075B784
      Related
      ENSP00000468549.3, ENST00000588086.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79682181..79736241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316776.1XP_054172751.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X10

    2. XM_054316773.1XP_054172748.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

    3. XM_054316766.1XP_054172741.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    4. XM_054316761.1XP_054172736.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    5. XM_054316760.1XP_054172735.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    6. XM_054316770.1XP_054172745.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

    7. XM_054316762.1XP_054172737.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    8. XM_054316767.1XP_054172742.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    9. XM_054316765.1XP_054172740.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    10. XM_054316763.1XP_054172738.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    11. XM_054316764.1XP_054172739.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    12. XM_054316772.1XP_054172747.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    13. XM_054316769.1XP_054172744.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

    14. XM_054316771.1XP_054172746.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    15. XM_054316774.1XP_054172749.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X8

    16. XM_054316775.1XP_054172750.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X9

    17. XM_054316768.1XP_054172743.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

    18. XM_054316777.1XP_054172752.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X11

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025090.3: Suppressed sequence

      Description
      NM_025090.3: This RefSeq was removed because currently there is not sufficient data to support this transcript.