S100a14 S100 calcium binding protein A14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100a14provided by RGD
Official Full Name: S100 calcium binding protein A14provided by RGD
Primary source: RGD:1595063
See related: Ensembl:ENSRNOG00000069413 AllianceGenome:RGD:1595063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chemokine receptor binding activity. Predicted to be involved in positive regulation of leukocyte chemotaxis; response to bacterium; and toll-like receptor 4 signaling pathway. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human S100A14 (S100 calcium binding protein A14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 21.0), Thymus (RPKM 13.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178305976..178308004)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (176008395..176010423)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138603 (e-PCR)
- UniSTS:220690

RH134161 (e-PCR)
- UniSTS:217443

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271312.2 → NP_001258241.1 protein S100-A14

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6A7N5, A6J6N8

Related

ENSRNOP00000087031.1, ENSRNOT00000106688.1

Conserved Domains (1) summary

cd05022
Location:16 → 101

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...