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    Nhlrc2 NHL repeat containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307986, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Nhlrc2provided by RGD
    Official Full Name
    NHL repeat containing 2provided by RGD
    Primary source
    RGD:1307348
    See related
    Ensembl:ENSRNOG00000016948 AllianceGenome:RGD:1307348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytosol. Orthologous to human NHLRC2 (NHL repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 157.8), Lung (RPKM 138.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nhlrc2 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265594915..265655647)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255589743..255648904)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277355619..277415940)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L19, pseudogene 2 Neighboring gene DNA cross-link repair 1A Neighboring gene uncharacterized LOC102547573 Neighboring gene uncharacterized LOC120100064 Neighboring gene adrenoceptor beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease. Paakkola T, et al. Hum Mol Genet, 2018 Dec 15. PMID 30239752

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NHL repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107444.2 → NP_001100914.1  NHL repeat-containing protein 2

      See identical proteins and their annotated locations for NP_001100914.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6APX7, A6JI26, D3ZLM5
      Related
      ENSRNOP00000022788.4, ENSRNOT00000022788.6
      Conserved Domains (4) summary
      cd03012
      Location:55 → 182
      TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...
      cd05819
      Location:163 → 208
      NHL; NHL repeat [structural motif]
      cd14951
      Location:261 → 623
      NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins
      cl18310
      Location:163 → 296
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      265594915..265655647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110139.2 → XP_038966067.1  NHL repeat-containing protein 2 isoform X1

      Conserved Domains (1) summary
      PLN02919
      Location:30 → 478
      PLN02919; haloacid dehalogenase-like hydrolase family protein

    RNA

    1. XR_010066447.1 RNA Sequence

    2. XR_010066446.1 RNA Sequence

    3. XR_010066448.1 RNA Sequence

    4. XR_010066449.1 RNA Sequence

    5. XR_351167.4 RNA Sequence

    6. XR_351166.4 RNA Sequence

    7. XR_005504465.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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