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    UTS2R urotensin 2 receptor [ Homo sapiens (human) ]

    Gene ID: 2837, updated on 2-Nov-2024

    Summary

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    Official Symbol
    UTS2Rprovided by HGNC
    Official Full Name
    urotensin 2 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:4468
    See related
    Ensembl:ENSG00000181408 MIM:600896; AllianceGenome:HGNC:4468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UTR; UTR2; GPR14; UR-2-R
    Summary
    Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    mouse all
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    Genomic context

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    See UTS2R in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82371765..82377458)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (83240931..83246624)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80329641..80335334)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80282821-80283426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80283427-80284032 Neighboring gene secreted and transmembrane 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80290146-80290948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80302606-80303141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13005 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:80309262-80309440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80309821-80310697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80313765-80314700 Neighboring gene Sharpr-MPRA regulatory region 9771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80320818-80321596 Neighboring gene testis expressed 19 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80334527-80335396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80337379-80337880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80337881-80338380 Neighboring gene uncharacterized LOC124904092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80343201-80343886 Neighboring gene uncharacterized LOC124904090 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80357274-80357880

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Urantide conformation and interaction with the urotensin-II receptor. Brancaccio D, et al. Arch Pharm (Weinheim), 2014 Mar. PMID 24357333
    2. Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands. Nassour H, et al. J Biol Chem, 2021 Sep. PMID 34389356, Free PMC Article
    3. Solution structure of urotensin-II receptor extracellular loop III and characterization of its interaction with urotensin-II. Boivin S, et al. Peptides, 2008 May. PMID 18423797
    4. Urotensin II: a novel target in human corpus cavernosum. d'Emmanuele di Villa Bianca R, et al. J Sex Med, 2010 May. PMID 19788716
    5. Three-dimensional model of the human urotensin-II receptor: docking of human urotensin-II and nonpeptide antagonists in the binding site and comparison with an antagonist pharmacophore model. Lescot E, et al. Proteins, 2008 Oct. PMID 18409194

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands.
      Title: Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands.
    2. Urotensin II receptor expression in patients with ulcerative colitis: a pilot study.
      Title: Urotensin II receptor expression in patients with ulcerative colitis: a pilot study.
    3. Novel Mutations in UTS2R are Associated with Adolescent Idiopathic Scoliosis in the Chinese Population.
      Title: Novel Mutations in UTS2R are Associated with Adolescent Idiopathic Scoliosis in the Chinese Population.
    4. ligand-induced activation of the chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, triggers a marked reduction in the biogenesis of autophagosomes.
      Title: Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.
    5. The role of Urotensin-II receptor in vasoconstriction and in the development of digestive tract cancers
      Title: Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.
    6. UII/GPR14 signaling was involved in the DSS-induced colonic inflammation and its inhibition may serve as a potential therapeutic target, which may be associated with the NF-kappaB signaling pathway.
      Title: UII/GPR14 is involved in NF-κB-mediated colonic inflammation in vivo and in vitro.
    7. UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
      Title: Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
    8. Urotensin II can induce the proliferation of BEL-7402 cells via the urotensin receptor mediated PKC/ERK/p38 MAPK signaling pathways.
      Title: Up-regulation of urotensin II and its receptor contributes to human hepatocellular carcinoma growth via activation of the PKC, ERK1/2, and p38 MAPK signaling pathways.
    9. Report interaction of urantide with urotensin II receptor.
      Title: Urantide conformation and interaction with the urotensin-II receptor.
    10. UTR protein and mRNA levels were increased in colon cancer cell lines and in colon adenoma and adenocarcinoma. UTR appears to be involved in the regulation of colon cancer cell invasion and motility.
      Title: Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables urotensin II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood circulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    urotensin-2 receptor
    Names
    G-protein coupled receptor 14
    UR-II-R
    urotensin II receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381897.1 → NP_001368826.1  urotensin-2 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC132938
      Consensus CDS
      CCDS11810.1
      UniProtKB/Swiss-Prot
      B2RMV8, Q9UKP6
      Conserved Domains (1) summary
      cd14999
      Location:53 → 326
      7tmA_UII-R; urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_018949.3 → NP_061822.1  urotensin-2 receptor

      See identical proteins and their annotated locations for NP_061822.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC132938
      Consensus CDS
      CCDS11810.1
      UniProtKB/Swiss-Prot
      B2RMV8, Q9UKP6
      Related
      ENSP00000323516.2, ENST00000313135.5
      Conserved Domains (1) summary
      cd14999
      Location:53 → 326
      7tmA_UII-R; urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      82371765..82377458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      83240931..83246624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UKP6.1 GenPept UniProtKB/Swiss-Prot:Q9UKP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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