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    FBXO9 F-box protein 9 [ Homo sapiens (human) ]

    Gene ID: 26268, updated on 28-Oct-2024

    Summary

    Official Symbol
    FBXO9provided by HGNC
    Official Full Name
    F-box protein 9provided by HGNC
    Primary source
    HGNC:HGNC:13588
    See related
    Ensembl:ENSG00000112146 MIM:609091; AllianceGenome:HGNC:13588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX9; VCIA1; NY-REN-57; dJ341E18.2
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 15.5), bone marrow (RPKM 13.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FBXO9 in Genome Data Viewer
    Location:
    6p12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53064998..53100873)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52904603..52940463)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52929796..52965671)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17287 Neighboring gene RNA component of 7SK nuclear ribonucleoprotein Neighboring gene ciliogenesis associated kinase 1 Neighboring gene uncharacterized LOC128092246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:52908870-52909424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17288 Neighboring gene uncharacterized LOC128031835 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2296 Neighboring gene glial cells missing transcription factor 1 Neighboring gene uncharacterized LOC124901513 Neighboring gene RNA, U6 small nuclear 464, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0936, DKFZp434C0118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box only protein 9
    Names
    F-box protein Fbx9
    cross-immune reaction antigen 1
    renal carcinoma antigen NY-REN-57

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012347.4NP_036479.1  F-box only protein 9 isoform 1

      See identical proteins and their annotated locations for NP_036479.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is shortest transcript yet it encodes the longest protein (isoform 1).
      Source sequence(s)
      AF176704, AL031178, BC000650
      Consensus CDS
      CCDS55023.1
      UniProtKB/Swiss-Prot
      A6NFW3, B3KMM6, O75986, Q59EH8, Q6PKH7, Q9NT57, Q9UK97, Q9Y593
      Related
      ENSP00000244426.6, ENST00000244426.10
      Conserved Domains (2) summary
      pfam12937
      Location:188239
      F-box-like; F-box-like
      cl00299
      Location:92123
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    2. NM_033480.3NP_258441.1  F-box only protein 9 isoform 2

      See identical proteins and their annotated locations for NP_258441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a different segment for the 5' UTR and 5' coding region, compared to variant 1. It uses a different translation start codon and the encoded protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL031178, AL137520
      Consensus CDS
      CCDS55022.1
      UniProtKB/Swiss-Prot
      Q9UK97
      Related
      ENSP00000326968.7, ENST00000323557.12
      Conserved Domains (2) summary
      pfam12937
      Location:178229
      F-box-like; F-box-like
      cl00299
      Location:82113
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    3. NM_033481.3NP_258442.2  F-box only protein 9 isoform 3

      See identical proteins and their annotated locations for NP_258442.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a different segment for the 5' UTR and lacks part of the 5' coding region, compared to variant 1. It uses a downstream translation start codon, with the resulting protein (isoform 3) having a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL031178, BC000650
      Consensus CDS
      CCDS55024.1
      Related
      ENSP00000359977.3, ENST00000370939.7
      Conserved Domains (2) summary
      pfam12937
      Location:144190
      F-box-like; F-box-like
      cl00299
      Location:4879
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      53064998..53100873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      52904603..52940463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)