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    ZBTB8B zinc finger and BTB domain containing 8B [ Homo sapiens (human) ]

    Gene ID: 728116, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZBTB8Bprovided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 8Bprovided by HGNC
    Primary source
    HGNC:HGNC:37057
    See related
    Ensembl:ENSG00000273274 AllianceGenome:HGNC:37057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF916B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB8B in Genome Data Viewer
    Location:
    1p35.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32465072..32496686)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32322988..32354613)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32930673..32962287)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 691 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:32903713-32904496 Neighboring gene RNA, 7SL, cytoplasmic 122, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 601 Neighboring gene uncharacterized LOC124903952 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33013203-33013387 Neighboring gene MPRA-validated peak165 silencer Neighboring gene zinc finger and BTB domain containing 8A Neighboring gene MPRA-validated peak166 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33072181-33072681 Neighboring gene uncharacterized LOC102723870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33077607-33078108

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    2. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    4. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    5. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ZBTB8A

    Homology

    Clone Names

    • DKFZp547H154

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 8B
    Names
    putative zinc finger and BTB domain-containing protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145720.2 → NP_001139192.1  zinc finger and BTB domain-containing protein 8B

      See identical proteins and their annotated locations for NP_001139192.1

      Status: VALIDATED

      Source sequence(s)
      AL033529, AL356986
      Consensus CDS
      CCDS44104.1
      UniProtKB/Swiss-Prot
      Q15DG5, Q5VXR5, Q69YT7, Q8NAP8
      Related
      ENSP00000476499.1, ENST00000609129.2
      Conserved Domains (4) summary
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:6 → 118
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13909
      Location:341 → 365
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32465072..32496686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32322988..32354613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NAP8.2 GenPept UniProtKB/Swiss-Prot:Q8NAP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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