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    GRIP1 glutamate receptor interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 23426, updated on 3-Nov-2024

    Summary

    Official Symbol
    GRIP1provided by HGNC
    Official Full Name
    glutamate receptor interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:18708
    See related
    Ensembl:ENSG00000155974 MIM:604597; AllianceGenome:HGNC:18708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIP; FRASRS3
    Summary
    This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
    Annotation information
    Note: GRIP1 (Gene ID: 23426) and NCOA2 (Gene ID: 10499) share the GRIP1 symbol/alias in common. GRIP1 is a widely used alternative name for nuclear receptor coactivator 2 (NCOA2), which can be confused with the official symbol for glutamate receptor-interacting protein 1 (GRIP1). [06 Jul 2018]
    Expression
    Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRIP1 in Genome Data Viewer
    Location:
    12q14.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (66347431..67069338, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (66326883..67048770, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (66741211..67463118, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6619 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105369811 Neighboring gene DNA helicase B Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:66801605-66802105 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:66890797-66891645 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:66891646-66892493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6620 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:66978252-66978488 Neighboring gene oxysterol binding protein like 9 pseudogene 4 Neighboring gene oxysterol binding protein like 9 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6621 Neighboring gene NANOG hESC enhancer GRCh37_chr12:67052705-67053206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4638 Neighboring gene Sharpr-MPRA regulatory region 5579 Neighboring gene VISTA enhancer hs1498 Neighboring gene NANOG hESC enhancer GRCh37_chr12:67175965-67176466 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:67224101-67224271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:67279097-67279597 Neighboring gene uncharacterized LOC124902956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:67461160-67461666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:67461667-67462171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4639 Neighboring gene uncharacterized LOC102724421 Neighboring gene RAB11A, member RAS oncogene family pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Fraser syndrome 3
    MedGen: C4540040 OMIM: 617667 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutamate receptor-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021400.2 RefSeqGene

      Range
      395190..726835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178074.2NP_001171545.1  glutamate receptor-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001171545.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 1.
      Source sequence(s)
      AC078889, AI190011, AK095519, BC115393, DA801887
      UniProtKB/TrEMBL
      F5H4N6
      Related
      ENSP00000446047.1, ENST00000538211.5
      Conserved Domains (1) summary
      cd00992
      Location:152235
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_001366722.1NP_001353651.1  glutamate receptor-interacting protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC078889, AC090710, AC122686, AC135251
      Consensus CDS
      CCDS91722.1
      UniProtKB/Swiss-Prot
      C9JT59, Q1RLM0, Q9Y3R0
      UniProtKB/TrEMBL
      F5H4N6
      Related
      ENSP00000352780.4, ENST00000359742.9
      Conserved Domains (1) summary
      cd00992
      Location:152235
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. NM_001366723.1NP_001353652.1  glutamate receptor-interacting protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC078888, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:178261
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    4. NM_001366724.1NP_001353653.1  glutamate receptor-interacting protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC078888, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:178261
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. NM_001379345.1NP_001366274.1  glutamate receptor-interacting protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC078888, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:178261
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    6. NM_001379346.1NP_001366275.1  glutamate receptor-interacting protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC078889, AC090710, AC122686, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:152235
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    7. NM_001379347.1NP_001366276.1  glutamate receptor-interacting protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC078888, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:178261
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    8. NM_001379348.1NP_001366277.1  glutamate receptor-interacting protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC078888, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:178261
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    9. NM_001379349.1NP_001366278.1  glutamate receptor-interacting protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC073530, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:153236
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    10. NM_001379351.1NP_001366280.1  glutamate receptor-interacting protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC073530, AC078889, AC090710, AC135251
      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:153236
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    11. NM_021150.4NP_066973.2  glutamate receptor-interacting protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC078889, AI190011, BC115393, DA801887
      Consensus CDS
      CCDS41807.1
      UniProtKB/TrEMBL
      F5H4N6
      Related
      ENSP00000381098.3, ENST00000398016.7
      Conserved Domains (1) summary
      cd00992
      Location:152235
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      66347431..67069338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428622.1XP_047284578.1  glutamate receptor-interacting protein 1 isoform X11

      Related
      ENSP00000439053.1, ENST00000538164.5
    2. XM_005268757.5XP_005268814.1  glutamate receptor-interacting protein 1 isoform X10

      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:126209
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. XM_047428620.1XP_047284576.1  glutamate receptor-interacting protein 1 isoform X8

    4. XM_047428619.1XP_047284575.1  glutamate receptor-interacting protein 1 isoform X7

    5. XM_005268754.5XP_005268811.1  glutamate receptor-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:153236
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    6. XM_047428617.1XP_047284573.1  glutamate receptor-interacting protein 1 isoform X3

    7. XM_047428621.1XP_047284577.1  glutamate receptor-interacting protein 1 isoform X9

    8. XM_047428616.1XP_047284572.1  glutamate receptor-interacting protein 1 isoform X2

    9. XM_047428618.1XP_047284574.1  glutamate receptor-interacting protein 1 isoform X5

    10. XM_017019100.2XP_016874589.1  glutamate receptor-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TLS6, F5H4N6
      Related
      ENSP00000513025.1, ENST00000696989.1
      Conserved Domains (1) summary
      cd00992
      Location:227310
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    11. XM_017019098.2XP_016874587.1  glutamate receptor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      F5H4N6
      Conserved Domains (1) summary
      cd00992
      Location:227310
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      66326883..67048770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371592.1XP_054227567.1  glutamate receptor-interacting protein 1 isoform X11

    2. XM_054371591.1XP_054227566.1  glutamate receptor-interacting protein 1 isoform X10

    3. XM_054371589.1XP_054227564.1  glutamate receptor-interacting protein 1 isoform X8

    4. XM_054371588.1XP_054227563.1  glutamate receptor-interacting protein 1 isoform X7

    5. XM_054371587.1XP_054227562.1  glutamate receptor-interacting protein 1 isoform X6

    6. XM_054371584.1XP_054227559.1  glutamate receptor-interacting protein 1 isoform X3

    7. XM_054371590.1XP_054227565.1  glutamate receptor-interacting protein 1 isoform X9

    8. XM_054371583.1XP_054227558.1  glutamate receptor-interacting protein 1 isoform X2

    9. XM_054371586.1XP_054227561.1  glutamate receptor-interacting protein 1 isoform X5

    10. XM_054371585.1XP_054227560.1  glutamate receptor-interacting protein 1 isoform X4

    11. XM_054371582.1XP_054227557.1  glutamate receptor-interacting protein 1 isoform X1