Nr1i2 nuclear receptor subfamily 1, group I, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nr1i2provided by RGD
Official Full Name: nuclear receptor subfamily 1, group I, member 2provided by RGD
Primary source: RGD:69057
See related: EnsemblRapid:ENSRNOG00000002906 AllianceGenome:RGD:69057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PXR
Summary: Enables nuclear receptor activity. Predicted to be involved in several processes, including cellular response to type I interferon; regulation of transcription by RNA polymerase II; and xenobiotic transport. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of gene expression. Predicted to be located in intermediate filament cytoskeleton and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Biomarker of cholestasis and epilepsy. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 320.5) and Kidney (RPKM 60.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (75965717..76006733)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (62460213..62496665)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (65022100..65058546)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct.
Title: High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct.
Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor.
Title: Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor.
PXR significantly increased neointimal formation in balloon-injured rat carotid arteries. PXR increased smooth muscle cell proliferation and migration via the induction of phosphorylation of ERK1/2 and p38 MAPK.
Title: Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries.
Acute hypoxia at high altitude can affect the expression of nuclear receptor PXR in rat liver
Title: [Effects of acute hypoxia on expression of pregnane X receptor in liver tissues of rats exposed to high altitude].
nuclear expression virtually disappeared in the late stage of cholestatic injury, after an initial increase
Title: Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
the results of combined analyses suggest that PXR's effects are due to transcriptional and post-transcriptional regulation with alteration of nongenotoxic signaling pathways and energy homeostasis.
Title: Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile.
In epileptic rats, P-glycoprotein expression regulates pregnane X receptor up-regulation in brain.
Title: Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
Metabolism of methiocarb and carbaryl alters PXR agonist activity.
Title: Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.
Drug-mediated activation of the pregnane X receptor reduced these adverse changes in rats, suggesting that the pregnane X receptor is a viable drug target to reduce ischaemic-type biliary lesions in recipients of liver transplants
Title: Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.
PXR in the midbrain may be required for the observed increase in 3alpha-5alpha-THP during proestrus, which has subsequent effects on motivated, reproductive behaviors.
Title: Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type I interferon	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor subfamily 1 group I member 2

Names: nuclear receptor subfamily 1, group 1, member 2; orphan nuclear receptor PXR; pregnane X receptor (nuclear receptor sub family 1, group I, member 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052980.2 → NP_443212.1 nuclear receptor subfamily 1 group I member 2

See identical proteins and their annotated locations for NP_443212.1

Status: VALIDATED

Source sequence(s)

AF151377, BC091138, CO575646

UniProtKB/Swiss-Prot

Q9R1A7

UniProtKB/TrEMBL

A6IR78

Related

ENSRNOP00000003934.3, ENSRNOT00000003934.6

Conserved Domains (2) summary

cl02596
Location:37 → 124

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:140 → 425

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

75965717..76006733

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088670.2 → XP_038944598.1 nuclear receptor subfamily 1 group I member 2 isoform X1

Conserved Domains (1) summary

cl11397
Location:22 → 226

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators