Slc15a2 solute carrier family 15 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc15a2provided by RGD
Official Full Name: solute carrier family 15 member 2provided by RGD
Primary source: RGD:61972
See related: EnsemblRapid:ENSRNOG00000002305 AllianceGenome:RGD:61972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables dipeptide transmembrane transporter activity; peptide:proton symporter activity; and tripeptide transmembrane transporter activity. Involved in dipeptide import across plasma membrane; metanephric proximal tubule development; and tripeptide import across plasma membrane. Located in apical plasma membrane. Orthologous to human SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 467.6), Brain (RPKM 101.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (77519565..77548609)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (64014182..64043228)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (66932664..66961708)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of ageing and hypertension on the expression and activity of PEPT2 in normal and hypertrophic hearts.
Title: Effect of ageing and hypertension on the expression and activity of PEPT2 in normal and hypertrophic hearts.
This study confirms the absence of Pept1 from rat lung alveolar epithelium in vitro. Functional Slc15a2/PEPT2 expression in type II-like cell monolayers suggests its involvement in oligopeptide lung disposition, and offers rationale for therapeutic development of di/tripeptides, peptidomimetics employing pulmonary drug delivery.
Title: Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.
Title: Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
No significant changes of pulmonary PEPT2 mRNA expression levels in rats with pulmonary fibrosis compared to the controls.
Title: [Expression of PEPT2 mRNA in lung tissue of rats with pulmonary fibrosis].
PEPT2 is functionally expressed in alveolar type II epithelial cells, but the expression decreases along with transdifferentiation.
Title: Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells.
These findings represent the first evidence that peptide transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular cells.
Title: Functional expression of SLC15 peptide transporters in rat thyroid follicular cells.
likely to play an important role in mucosal peptide metabolism and may represent a novel target for therapeutic efforts in upper airway diseases
Title: Expression, localisation and functional implications of the transporter protein PEPT2 in the upper respiratory tract.
there are no major differences in the substrate recognition pattern of hPEPT1 and rPEPT2 with regard to the ACE inhibitors tested.
Title: Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.
Carnosine uptake in neonatal rat astrocytes was inhibited by dipeptides but not by histidine and also showed saturable transport.
Title: PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

BF405220 (e-PCR)
- UniSTS:247834

RH139643 (e-PCR)
- UniSTS:221727

RH127511 (e-PCR)
- UniSTS:210821

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity oligopeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oligopeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables peptide:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables peptide:proton symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables tripeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in dipeptide import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dipeptide transport	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in metanephric proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligopeptide transport	ISO Inferred from Sequence Orthology more info
involved_in peptidoglycan transport	ISO Inferred from Sequence Orthology more info
involved_in peptidoglycan transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal absorption	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tripeptide import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: solute carrier family 15 member 2

Names: kidney H(+)/peptide cotransporter; peptide transporter 2; solute carrier family 15 (H+/peptide transporter), member 2; solute carrier family 15 (oligopeptide transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031672.2 → NP_113860.2 solute carrier family 15 member 2

See identical proteins and their annotated locations for NP_113860.2

Status: VALIDATED

Source sequence(s)

BC085327

UniProtKB/TrEMBL

A0A0H2UHA7, A0A8I6A6Q4, A6IRB4

Related

ENSRNOP00000078734.1, ENSRNOT00000120269.2

Conserved Domains (2) summary

TIGR00926
Location:69 → 707

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

pfam00854
Location:122 → 441

PTR2; POT family