U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GRM8 glutamate metabotropic receptor 8 [ Homo sapiens (human) ]

    Gene ID: 2918, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GRM8provided by HGNC
    Official Full Name
    glutamate metabotropic receptor 8provided by HGNC
    Primary source
    HGNC:HGNC:4600
    See related
    Ensembl:ENSG00000179603 MIM:601116; AllianceGenome:HGNC:4600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUR8; mGlu8; GPRC1H; MGLUR8
    Summary
    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 1.2), testis (RPKM 1.0) and 9 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GRM8 in Genome Data Viewer
    Location:
    7q31.33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (126438598..127252941, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (127750296..128564614, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (126078652..126892995, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375487 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:125549855-125550449 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:125555064-125555651 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:125555652-125556238 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:125563618-125564252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26574 Neighboring gene uncharacterized LOC105375488 Neighboring gene uncharacterized LOC101928357 Neighboring gene poly(A) binding protein cytoplasmic 4 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:126214200-126215399 Neighboring gene uncharacterized LOC107986843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26578 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:126340799-126341998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26581 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:126418019-126418567 Neighboring gene uncharacterized LOC124901742 Neighboring gene microRNA 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18590 Neighboring gene GRM8 antisense RNA 1 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127032217-127032717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18593 Neighboring gene zinc finger protein 800

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task. Bauer LO, et al. Clin Neurophysiol, 2020 Jun. PMID 32299001, Free PMC Article
    2. Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. Chen AC, et al. Am J Med Genet B Neuropsychiatr Genet, 2009 Apr 5. PMID 18618593, Free PMC Article
    3. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Malherbe P, et al. Brain Res Mol Brain Res, 1999 Apr 20. PMID 10216218
    4. Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain. Yanagawa M, et al. J Biol Chem, 2013 Apr 5. PMID 23420844, Free PMC Article
    5. The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. Scherer SW, et al. Genomics, 1997 Sep 1. PMID 9299241

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.
      Title: Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.
    2. GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.
      Title: GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.
    3. Transcriptional activation of GRM8 lung squamous cell carcinoma tumor cells induced cell proliferation by inhibiting cAMP pathway and activating MAPK pathway.
      Title: Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer.
    4. rs712723 in GRM8 was selected for genotyping. The allele C and genotype CC (allele C: OR 1.48, 95% CI 1.13-1.94; genotype CC: OR 1.71, 95% CI 1.09-2.68) of rs712723 polymorphism was found to have a significant association with risk of schizophrenia while allele T (P = 0.003) and genotype TT (P = 0.028) frequencies were found lower in control patients.
      Title: TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an Iranian population: a case-control study.
    5. This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence).
      Title: What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?
    6. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population
      Title: Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.
    7. These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
      Title: Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.
    8. Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region.
      Title: A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.
    9. propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8).
      Title: A candidate syntenic genetic locus is associated with voluntary exercise levels in mice and humans.
    10. The GRM8 gene might play an important role in the pathogenesis of schizophrenia.
      Title: Association analysis of the GRM8 gene with schizophrenia in the Uygur Chinese population.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of carotid atherosclerosis in HIV-infected men.
    EBI GWAS Catalog
    Chemerin, a novel adipokine in the regulation of angiogenesis.
    EBI GWAS Catalog
    Genome-wide association scan of trait depression.
    EBI GWAS Catalog
    Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ41058, MGC126724

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables group III metabotropic glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    metabotropic glutamate receptor 8
    Names
    glutamate receptor, metabotropic 8

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029532.2 RefSeqGene

      Range
      5000..819343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000845.3 → NP_000836.2  metabotropic glutamate receptor 8 isoform a precursor

      See identical proteins and their annotated locations for NP_000836.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 4 and 5, encodes isoform a.
      Source sequence(s)
      AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
      Consensus CDS
      CCDS5794.1
      UniProtKB/Swiss-Prot
      A4D0Y3, B0FZ74, B0M0L0, O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
      UniProtKB/TrEMBL
      A8K2D2
      Related
      ENSP00000344173.2, ENST00000339582.7
      Conserved Domains (3) summary
      cd15454
      Location:582 → 892
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:512 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:40 → 504
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    2. NM_001127323.1 → NP_001120795.1  metabotropic glutamate receptor 8 isoform b precursor

      See identical proteins and their annotated locations for NP_001120795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to transcript variant 1, resulting in an isoform (b) of the same length, but with 16 different amino acids at the C-terminus compared to isoform a. This variant was designated as HmGluR8b by Malherbe et al, 1999 (PMID:10216218). Variants 2 and 6 both encode the same isoform (b).
      Source sequence(s)
      AJ236921, AK315203, BG202742, BG211606
      Consensus CDS
      CCDS47696.1
      UniProtKB/TrEMBL
      A8K2D2
      Related
      ENSP00000351142.3, ENST00000358373.8
      Conserved Domains (3) summary
      cd15454
      Location:582 → 892
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:512 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:40 → 504
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    3. NM_001371083.1 → NP_001358012.1  metabotropic glutamate receptor 8 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1 and 5, encodes isoform a.
      Source sequence(s)
      AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533, KF458593
      Consensus CDS
      CCDS5794.1
      UniProtKB/Swiss-Prot
      A4D0Y3, B0FZ74, B0M0L0, O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
      UniProtKB/TrEMBL
      A8K2D2
      Related
      ENSP00000516625.1, ENST00000706917.1
      Conserved Domains (3) summary
      cd15454
      Location:582 → 892
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:512 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:40 → 504
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    4. NM_001371084.1 → NP_001358013.1  metabotropic glutamate receptor 8 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1 and 4, encodes isoform a.
      Source sequence(s)
      AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
      Consensus CDS
      CCDS5794.1
      UniProtKB/Swiss-Prot
      A4D0Y3, B0FZ74, B0M0L0, O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165
      UniProtKB/TrEMBL
      A8K2D2
      Conserved Domains (3) summary
      cd15454
      Location:582 → 892
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:512 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:40 → 504
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    5. NM_001371085.1 → NP_001358014.1  metabotropic glutamate receptor 8 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
      Consensus CDS
      CCDS47696.1
      UniProtKB/TrEMBL
      A8K2D2
      Related
      ENSP00000516624.1, ENST00000706916.1
      Conserved Domains (3) summary
      cd15454
      Location:582 → 892
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:512 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:40 → 504
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    6. NM_001371086.1 → NP_001358015.1  metabotropic glutamate receptor 8 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (c).
      Source sequence(s)
      AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
      UniProtKB/TrEMBL
      A0A9L9PYG5, A8K2D2
      Related
      ENSP00000516623.1, ENST00000706915.1

    7. NM_001371087.1 → NP_001358016.1  metabotropic glutamate receptor 8 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
      Conserved Domains (3) summary
      cd15454
      Location:377 → 687
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:307 → 357
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1 → 299
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    8. NM_001371088.1 → NP_001358017.1  metabotropic glutamate receptor 8 isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC000099, AC000363, AC000367, AC002424, AC002497, AC002533

    RNA

    1. NR_028041.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the central coding region that results in a frameshift, compared to transcript variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant was designated as HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
      Source sequence(s)
      AJ236922, AK315203, BC093725, BG202742, BG211606
      Related
      ENST00000341617.7

    2. NR_163849.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533

    3. NR_163850.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      126438598..127252941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420269.1 → XP_047276225.1  metabotropic glutamate receptor 8 isoform X1

    2. XM_047420271.1 → XP_047276227.1  metabotropic glutamate receptor 8 isoform X3

    3. XM_017012077.2 → XP_016867566.1  metabotropic glutamate receptor 8 isoform X3

      Conserved Domains (3) summary
      cd15454
      Location:377 → 687
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:307 → 357
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1 → 299
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    4. XM_047420272.1 → XP_047276228.1  metabotropic glutamate receptor 8 isoform X3

    5. XM_017012078.2 → XP_016867567.1  metabotropic glutamate receptor 8 isoform X3

      Conserved Domains (3) summary
      cd15454
      Location:377 → 687
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:307 → 357
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1 → 299
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    6. XM_047420270.1 → XP_047276226.1  metabotropic glutamate receptor 8 isoform X2

    7. XM_017012075.2 → XP_016867564.1  metabotropic glutamate receptor 8 isoform X3

      Conserved Domains (3) summary
      cd15454
      Location:377 → 687
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:307 → 357
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1 → 299
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    8. XM_017012076.2 → XP_016867565.1  metabotropic glutamate receptor 8 isoform X3

      Conserved Domains (3) summary
      cd15454
      Location:377 → 687
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:307 → 357
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1 → 299
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    9. XM_047420276.1 → XP_047276232.1  metabotropic glutamate receptor 8 isoform X3

    10. XM_017012079.2 → XP_016867568.1  metabotropic glutamate receptor 8 isoform X3

      Conserved Domains (3) summary
      cd15454
      Location:377 → 687
      7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:307 → 357
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1 → 299
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    11. XM_047420275.1 → XP_047276231.1  metabotropic glutamate receptor 8 isoform X4

    12. XM_047420274.1 → XP_047276230.1  metabotropic glutamate receptor 8 isoform X4

    13. XM_047420273.1 → XP_047276229.1  metabotropic glutamate receptor 8 isoform X4

    14. XM_047420277.1 → XP_047276233.1  metabotropic glutamate receptor 8 isoform X5

    RNA

    1. XR_007060010.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      127750296..128564614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358000.1 → XP_054213975.1  metabotropic glutamate receptor 8 isoform X1

    2. XM_054358007.1 → XP_054213982.1  metabotropic glutamate receptor 8 isoform X3

    3. XM_054358002.1 → XP_054213977.1  metabotropic glutamate receptor 8 isoform X3

    4. XM_054358008.1 → XP_054213983.1  metabotropic glutamate receptor 8 isoform X3

    5. XM_054358005.1 → XP_054213980.1  metabotropic glutamate receptor 8 isoform X3

    6. XM_054358001.1 → XP_054213976.1  metabotropic glutamate receptor 8 isoform X2

    7. XM_054358003.1 → XP_054213978.1  metabotropic glutamate receptor 8 isoform X3

    8. XM_054358004.1 → XP_054213979.1  metabotropic glutamate receptor 8 isoform X3

    9. XM_054358012.1 → XP_054213987.1  metabotropic glutamate receptor 8 isoform X3

    10. XM_054358006.1 → XP_054213981.1  metabotropic glutamate receptor 8 isoform X3

    11. XM_054358011.1 → XP_054213986.1  metabotropic glutamate receptor 8 isoform X4

    12. XM_054358010.1 → XP_054213985.1  metabotropic glutamate receptor 8 isoform X4

    13. XM_054358009.1 → XP_054213984.1  metabotropic glutamate receptor 8 isoform X4

    14. XM_054358013.1 → XP_054213988.1  metabotropic glutamate receptor 8 isoform X5

    RNA

    1. XR_008487567.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00222.2 GenPept UniProtKB/Swiss-Prot:O00222

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous