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    BICDL2 BICD family like cargo adaptor 2 [ Homo sapiens (human) ]

    Gene ID: 146439, updated on 28-Oct-2024

    Summary

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    Official Symbol
    BICDL2provided by HGNC
    Official Full Name
    BICD family like cargo adaptor 2provided by HGNC
    Primary source
    HGNC:HGNC:33584
    See related
    Ensembl:ENSG00000162069 MIM:617003; AllianceGenome:HGNC:33584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BICDR2; BICDR-2; CCDC64B
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in colon (RPKM 12.5), skin (RPKM 11.3) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BICDL2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3027682..3036944, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3054254..3063516, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3077683..3086945, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:3070698-3071897 Neighboring gene TNF receptor superfamily member 12A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3073371-3074015 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3074016-3074659 Neighboring gene host cell factor C1 regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3076940-3077746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7105 Neighboring gene THO complex subunit 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3079359-3080163 Neighboring gene uncharacterized LOC100128770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3087655-3088542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3097443-3098022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3099514-3100106 Neighboring gene matrix metallopeptidase 25 Neighboring gene sialidase-like Neighboring gene MMP25 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3109609-3110514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3117783-3118302 Neighboring gene RNA, U1 small nuclear 125, pseudogene Neighboring gene interleukin 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Large-scale analysis of the human ubiquitin-related proteome. Matsumoto M, et al. Proteomics, 2005 Nov. PMID 16196087
    2. CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. Lim SH, et al. Mol Syst Biol, 2022 Feb. PMID 35156780, Free PMC Article
    3. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Zhou Y, et al. Nat Biotechnol, 2023 Jan. PMID 36217030, Free PMC Article
    4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC158069

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to secretory granule transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BICD family-like cargo adapter 2
    Names
    BICD-related protein 2
    bicaudal D-related protein 2
    coiled-coil domain containing 64B
    coiled-coil domain-containing protein 64B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103175.2 → NP_001096645.1  BICD family-like cargo adapter 2

      See identical proteins and their annotated locations for NP_001096645.1

      Status: VALIDATED

      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS45393.1
      UniProtKB/Swiss-Prot
      A1A5D9, Q658L9
      UniProtKB/TrEMBL
      A0A2R8Y2X6
      Related
      ENSP00000373998.4, ENST00000389347.4
      Conserved Domains (2) summary
      COG1196
      Location:192 → 450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 296
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001369667.1 → NP_001356596.1  BICD family-like cargo adapter 2

      Status: VALIDATED

      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS45393.1
      UniProtKB/Swiss-Prot
      A1A5D9, Q658L9
      UniProtKB/TrEMBL
      A0A2R8Y2X6
      Related
      ENSP00000459043.1, ENST00000572449.6
      Conserved Domains (2) summary
      COG1196
      Location:192 → 450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 296
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3027682..3036944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255135.5 → XP_005255192.1  BICD family-like cargo adapter 2 isoform X1

      See identical proteins and their annotated locations for XP_005255192.1

      UniProtKB/Swiss-Prot
      A1A5D9, Q658L9
      UniProtKB/TrEMBL
      A0A2R8Y2X6
      Conserved Domains (2) summary
      COG1196
      Location:192 → 450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 296
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_011522391.3 → XP_011520693.1  BICD family-like cargo adapter 2 isoform X2

      UniProtKB/TrEMBL
      A0A2R8Y2X6
      Conserved Domains (1) summary
      cl19219
      Location:118 → 227
      DUF342; Protein of unknown function (DUF342)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3054254..3063516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379675.1 → XP_054235650.1  BICD family-like cargo adapter 2 isoform X1

      UniProtKB/Swiss-Prot
      A1A5D9, Q658L9

    2. XM_054379676.1 → XP_054235651.1  BICD family-like cargo adapter 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A5D9.2 GenPept UniProtKB/Swiss-Prot:A1A5D9

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