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    PANTR1 POU3F3 adjacent non-coding transcript 1 [ Homo sapiens (human) ]

    Gene ID: 100506421, updated on 17-Jun-2024

    Summary

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    Official Symbol
    PANTR1provided by HGNC
    Official Full Name
    POU3F3 adjacent non-coding transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:49513
    See related
    Ensembl:ENSG00000233639 MIM:618169; AllianceGenome:HGNC:49513
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC01158; linc-Brn1a; linc-POU3F3
    Summary
    Predicted to act upstream of or within regulation of gene expression. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 2.2) and kidney (RPKM 1.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See PANTR1 in Genome Data Viewer
    Location:
    2q12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (104805425..104853183, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (105265303..105314364, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105421883..105469641, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:105362448-105363647 Neighboring gene long intergenic non-protein coding RNA 1114 Neighboring gene high mobility group box 3 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105460844-105461368 Neighboring gene VISTA enhancer hs1553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11835 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:105470177-105470766 Neighboring gene uncharacterized LOC124908045 Neighboring gene POU class 3 homeobox 3 Neighboring gene long intergenic non-protein coding RNA 1159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion. Li Y, et al. Biomed Pharmacother, 2018 Sep. PMID 29906746
    2. Understanding the Role of lncRNAs in Nervous System Development. Clark BS, et al. Adv Exp Med Biol, 2017. PMID 28815543, Free PMC Article
    3. Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3. Lang HL, et al. Eur Rev Med Pharmacol Sci, 2017 Mar. PMID 28338200
    4. LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5. Zhang L, et al. Kidney Blood Press Res, 2021. PMID 34352801
    5. Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p. Zeng Q, et al. BMC Pulm Med, 2020 Jul 2. PMID 32615948, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5.
      Title: LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5.
    2. lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587.
      Title: lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587.
    3. Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p.
      Title: Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p.
    4. LncRNA POU3F3 overexpression led to down-regulated TGF-beta1 expression, while exogenous TGF-b1 and TGF-b1 inhibitor treatment did not significantly change the expression level of lncRNA POU3F3. Therefore, lncRNA POU3F3 may promote cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-b1
      Title: LncRNA POU3F3 promotes cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1.
    5. Our study supports the first evidence that linc-POU3F3 plays an oncogenic role in hepatocellular carcinoma.
      Title: Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • long intergenic non-protein coding RNA 1158

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037883.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC018730, AK096498, BF700938
      Related
      ENST00000443988.7

    2. NR_131233.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' terminal exon, uses an alternate splice site at an internal exon, and has a shorter 3' terminal exon, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC018730, CK004193
      Related
      ENST00000447876.5

    3. NR_131234.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at an internal exon and has a shorter 3' terminal exon, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC018730, AL036798, BF700938
      Related
      ENST00000413121.7

    4. NR_131235.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site at an internal exon and has a shorter 3' terminal exon, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC018730, AI879178, BF700938
      Related
      ENST00000454729.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      104805425..104853183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      105265303..105314364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials