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    DPPA2 developmental pluripotency associated 2 [ Homo sapiens (human) ]

    Gene ID: 151871, updated on 28-Oct-2024

    Summary

    Official Symbol
    DPPA2provided by HGNC
    Official Full Name
    developmental pluripotency associated 2provided by HGNC
    Primary source
    HGNC:HGNC:19197
    See related
    Ensembl:ENSG00000163530 MIM:614445; AllianceGenome:HGNC:19197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT100; PESCRG1; ECAT15-2
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in system development. Predicted to act upstream of or within several processes, including epigenetic regulation of gene expression; lung-associated mesenchyme development; and positive regulation of stem cell proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis (RPKM 2.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DPPA2 in Genome Data Viewer
    Location:
    3q13.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (109293788..109316517, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (112014076..112036840, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (109012635..109035364, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1236, pseudogene Neighboring gene BRD7 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:109043097-109043597 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:109054673-109055281 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109055282-109055890 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109055891-109056498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:109057717-109058324 Neighboring gene developmental pluripotency associated 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:109066679-109067180 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109074429-109075164 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:109075165-109075898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109075899-109076634 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:109085761-109085928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:109114646-109115452 Neighboring gene RLIG1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    developmental pluripotency-associated protein 2
    Names
    cancer/testis antigen 100
    embryonic stem cell (ESC) associated transcript 15-2
    pluripotent embryonic stem cell-related gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138815.4NP_620170.3  developmental pluripotency-associated protein 2

      See identical proteins and their annotated locations for NP_620170.3

      Status: VALIDATED

      Source sequence(s)
      AA460929, AY283672, BC018070
      Consensus CDS
      CCDS2956.1
      UniProtKB/Swiss-Prot
      Q7Z7J5, Q8WVF0
      Related
      ENSP00000417710.1, ENST00000478945.1
      Conserved Domains (3) summary
      smart00513
      Location:99122
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14047
      Location:220286
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:133215
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      109293788..109316517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512444.4XP_011510746.1  developmental pluripotency-associated protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011510746.1

      UniProtKB/Swiss-Prot
      Q7Z7J5, Q8WVF0
      Conserved Domains (3) summary
      smart00513
      Location:99122
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14047
      Location:220286
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:133215
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates
    2. XM_011512445.3XP_011510747.1  developmental pluripotency-associated protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011510747.1

      UniProtKB/Swiss-Prot
      Q7Z7J5, Q8WVF0
      Conserved Domains (3) summary
      smart00513
      Location:99122
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14047
      Location:220286
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:133215
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates
    3. XM_011512443.2XP_011510745.1  developmental pluripotency-associated protein 2 isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:108131
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14047
      Location:229295
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:142224
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      112014076..112036840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345349.1XP_054201324.1  developmental pluripotency-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q7Z7J5, Q8WVF0
    2. XM_054345350.1XP_054201325.1  developmental pluripotency-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q7Z7J5, Q8WVF0
    3. XM_054345348.1XP_054201323.1  developmental pluripotency-associated protein 2 isoform X1