HSPBP1 HSPA (Hsp70) binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSPBP1provided by HGNC
Official Full Name: HSPA (Hsp70) binding protein 1provided by HGNC
Primary source: HGNC:HGNC:24989
See related: Ensembl:ENSG00000133265 MIM:612939; AllianceGenome:HGNC:24989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FES1
Summary: Enables molecular sequestering activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Is active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19q13.42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (55262223..55280383, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (58356168..58375917, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (55773591..55791751, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.
Title: HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.
HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.
Title: HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.
The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.
Title: The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.
Circulating HspBp1 is associated with progression of HIV infection and can be used as a new marker to predict the prognosis and management of HIV infection
Title: HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.
Findings indicate a critical role of HspBP1 in differential CHIP/Hsp70 activities in neuronal and glial cells and the greater neuronal vulnerability to misfolded proteins in neurodegenerative diseases.
Title: Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.
downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes
Title: Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.
our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-kappaB-mediated activation of viral transcription.
Title: HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.
Oxidative stress, inducing formation of disulfide bond, can affect stability and conformational mobility of human HspB1.
Title: Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1.
BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes
Title: Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.
shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex
Title: Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables molecular sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hsp70-binding protein 1

Names: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; heat shock protein-binding protein 1; hsp70 interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130106.2 → NP_001123578.1 hsp70-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001123578.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB020592, AF217996, BM853303, BU630679

Consensus CDS

CCDS33111.1

UniProtKB/Swiss-Prot

B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

Related

ENSP00000255631.4, ENST00000255631.9

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1
NM_001297600.2 → NP_001284529.1 hsp70-binding protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (1).

Source sequence(s)

AB020592, AF217996, AI859141, AK294358, DB500673

UniProtKB/Swiss-Prot

Q9NZL4

Related

ENSP00000467574.1, ENST00000587922.5

Conserved Domains (3) summary

cd00020
Location:248 → 347

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam08609
Location:91 → 185

Fes1; Nucleotide exchange factor Fes1

sd00043
Location:134 → 176

ARM; armadillo repeat [structural motif]
NM_012267.5 → NP_036399.3 hsp70-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_036399.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB020592, BM853303, BU630679

Consensus CDS

CCDS33111.1

UniProtKB/Swiss-Prot

B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

Related

ENSP00000398244.1, ENST00000433386.7

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

55262223..55280383 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011526691.2 → XP_011524993.1 hsp70-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_011524993.1

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1
XM_024451436.2 → XP_024307204.1 hsp70-binding protein 1 isoform X1

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1
XM_017026544.3 → XP_016882033.1 hsp70-binding protein 1 isoform X2

UniProtKB/Swiss-Prot

B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1
XM_005258701.4 → XP_005258758.1 hsp70-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_005258758.1

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1
XM_024451437.2 → XP_024307205.1 hsp70-binding protein 1 isoform X2

UniProtKB/Swiss-Prot

B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

Conserved Domains (2) summary

sd00043
Location:88 → 130

ARM; armadillo repeat [structural motif]

pfam08609
Location:45 → 139

Fes1; Nucleotide exchange factor Fes1
XM_017026545.2 → XP_016882034.1 hsp70-binding protein 1 isoform X3