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    LIN37 lin-37 DREAM MuvB core complex component [ Homo sapiens (human) ]

    Gene ID: 55957, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LIN37provided by HGNC
    Official Full Name
    lin-37 DREAM MuvB core complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:33234
    See related
    Ensembl:ENSG00000267796 AllianceGenome:HGNC:33234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F25965; lin-37; ZK418.4
    Summary
    This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 7.7), placenta (RPKM 6.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LIN37 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35748576..35754519)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38293885..38299832)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36239477..36245420)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14497 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36234871-36235031 Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36238731-36239245 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36239246-36239760 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene proline and serine rich 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation. Uxa S, et al. Nucleic Acids Res, 2019 Sep 26. PMID 31400114, Free PMC Article
    2. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Litovchick L, et al. Genes Dev, 2011 Apr 15. PMID 21498570, Free PMC Article
    3. The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. Iness AN, et al. Oncogene, 2019 Feb. PMID 30206359, Free PMC Article
    4. Structural mechanisms of DREAM complex assembly and regulation. Guiley KZ, et al. Genes Dev, 2015 May 1. PMID 25917549, Free PMC Article
    5. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Schmit F, et al. Cell Cycle, 2007 Aug 1. PMID 17671431

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abrogation of DREAM function by knockout of the DREAM component LIN37 results in a reduced repression of cell-cycle genes.
      Title: DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: PSENEN

    Homology

    Clone Names

    • MGC9505

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Myb complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-37 homolog
    Names
    antolefinin
    lin-37 homolog
    protein F25965

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369780.1 → NP_001356709.1  protein lin-37 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC002398, AD000671, KC877720, KC877725
      Conserved Domains (1) summary
      pfam15306
      Location:70 → 226
      LIN37

    2. NM_019104.3 → NP_061977.1  protein lin-37 homolog isoform 1

      See identical proteins and their annotated locations for NP_061977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC009071, CB152701, DC396639
      Consensus CDS
      CCDS62642.1
      UniProtKB/Swiss-Prot
      A8KAQ1, O14557, Q7Z2T9, Q96GY3
      Related
      ENSP00000301159.7, ENST00000301159.14
      Conserved Domains (1) summary
      pfam15306
      Location:84 → 240
      LIN37

    RNA

    1. NR_163146.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC002398, AD000671, KC877720, KC877725

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35748576..35754519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38293885..38299832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96GY3.1 GenPept UniProtKB/Swiss-Prot:Q96GY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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