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    HRES1 HTLV-1 related endogenous sequence (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 3272, updated on 10-Feb-2024

    Summary

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    Official Symbol
    HRES1provided by HGNC
    Official Full Name
    HTLV-1 related endogenous sequence (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:5180
    See related
    MIM:143025
    Gene type
    pseudo
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRES-1; HRES-1/p28
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    1q42

    Bibliography

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    Related articles in PubMed

    1. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. Godavarthy A, et al. JCI Insight, 2020 Jan 16. PMID 31805010, Free PMC Article
    2. DNA methylation modulates HRES1/p28 expression in B cells from patients with Lupus. Fali T, et al. Autoimmunity, 2014 Jun. PMID 24117194, Free PMC Article
    3. Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus. Pullmann R Jr, et al. Arthritis Rheum, 2008 Feb. PMID 18240231
    4. Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Gergely P Jr, et al. Clin Immunol, 2005 Aug. PMID 15894513
    5. Molecular analysis of endogenous retrovirus HRES-1: identification of frameshift mutations in region encoding putative 28-kDa autoantigen. Lefranc D, et al. Biochem Biophys Res Commun, 2001 May 4. PMID 11327721

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The HBZ protein is localized to heterochromatin and capable of repressing JUN activity and viral transcription.
      Title: Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs.
    2. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.
      Title: Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.
    3. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants.
    4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution.
    5. The HRES-1 locus represents a recombination hot spot at the 1q42 chromosomal region that influences the development and disease manifestations of systemic lupus erythematosus
      Title: Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus.
    7. Observational study of genotype prevalence. (HuGE Navigator)
      Title: HFE mutations and hemochromatosis in Danish patients admitted for HFE genotyping.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007238.1: Suppressed sequence

      Description
      NM_001007238.1: This RefSeq was permanently suppressed because it is based on sequence from an endogenous retrovirus.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13985.1 GenPept UniProtKB/Swiss-Prot:P13985

    Gene LinkOut

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