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    INPP4B inositol polyphosphate-4-phosphatase type II B [ Homo sapiens (human) ]

    Gene ID: 8821, updated on 13-Nov-2024

    Summary

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    Official Symbol
    INPP4Bprovided by HGNC
    Official Full Name
    inositol polyphosphate-4-phosphatase type II Bprovided by HGNC
    Primary source
    HGNC:HGNC:6075
    See related
    Ensembl:ENSG00000109452 MIM:607494; AllianceGenome:HGNC:6075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INPP4B in Genome Data Viewer
    Location:
    4q31.21
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (142023160..142846535, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (145340544..146163746, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (142944313..143767688, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:142501441-142502640 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:142546083-142546797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21938 Neighboring gene long intergenic non-protein coding RNA 2276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:142628696-142629196 Neighboring gene interleukin 15 Neighboring gene MPRA-validated peak5125 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:142803658-142804281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:142804282-142804904 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:142823512-142824114 Neighboring gene ribosomal protein L5 pseudogene 13 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 4 Neighboring gene uncharacterized LOC101927613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21939 Neighboring gene uncharacterized LOC105377457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:143768211-143768797 Neighboring gene uncharacterized LOC124900788 Neighboring gene USP38 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21940 Neighboring gene LysM domain containing 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. Perez-Lorenzo R, et al. J Invest Dermatol, 2014 May. PMID 24288008
    2. INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway. Chen Y, et al. J Cell Mol Med, 2018 May. PMID 29516642, Free PMC Article
    3. Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells. Kim JS, et al. Cancer Biol Ther, 2012 Nov. PMID 22895072, Free PMC Article
    4. Down-regulation of Inositol Polyphosphate 4-Phosphatase Type II Expression in Colorectal Carcinoma. Sung JY, et al. Anticancer Res, 2017 Oct. PMID 28982866
    5. INPP4B overexpression suppresses migration, invasion and angiogenesis of human prostate cancer cells. Chen H, et al. Clin Exp Pharmacol Physiol, 2017 Jun. PMID 28261855

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Preliminary Study of the Role of INPP4B in Promoting Colorectal Cancer Metastasis and the Mechanisms Involved].
      Title: [Preliminary Study of the Role of INPP4B in Promoting Colorectal Cancer Metastasis and the Mechanisms Involved].
    2. Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells.
      Title: Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells.
    3. INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis.
      Title: INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis.
    4. Investigating the multifaceted cooperation of autophagy, PI3K/AKT signaling pathways, and INPP4B gene in de novo acute myeloid leukemia patients.
      Title: Investigating the multifaceted cooperation of autophagy, PI3K/AKT signaling pathways, and INPP4B gene in de novo acute myeloid leukemia patients.
    5. Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
      Title: Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
    6. The INPP4B paradox: Like PTEN, but different.
      Title: The INPP4B paradox: Like PTEN, but different.
    7. INPP4B promotes PI3Kalpha-dependent late endosome formation and Wnt/beta-catenin signaling in breast cancer.
      Title: INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.
    8. Exosomes derived from human bone marrow mesenchymal stem cells transfer miR-222-3p to suppress acute myeloid leukemia cell proliferation by targeting IRF2/INPP4B.
      Title: Exosomes derived from human bone marrow mesenchymal stem cells transfer miR-222-3p to suppress acute myeloid leukemia cell proliferation by targeting IRF2/INPP4B.
    9. IRF2-INPP4B axis inhibits apoptosis of acute myeloid leukaemia cells via regulating T helper 1/2 cell differentiation.
      Title: IRF2-INPP4B axis inhibits apoptosis of acute myeloid leukaemia cells via regulating T helper 1/2 cell differentiation.
    10. Expression and functional characterization of INPP4B in gallbladder cancer patients and gallbladder cancer cells.
      Title: Expression and functional characterization of INPP4B in gallbladder cancer patients and gallbladder cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (64)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC132014

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables inositol-1,3,4-trisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate 4-phosphatase type II
    Names
    inositol polyphosphate 4-phosphatase II; 4-phosphatase II
    inositol polyphosphate-4-phosphatase, type II, 105kDa
    type II inositol 3,4-bisphosphate 4-phosphatase
    NP_001095139.1
    NP_001317969.1
    NP_001372263.1
    NP_001372264.1
    NP_001372265.1
    NP_001372266.1
    NP_001372267.1
    NP_001372268.1
    NP_001372269.1
    NP_001372270.1
    NP_001372271.1
    NP_001372272.1
    NP_001372273.1
    NP_001372276.1
    NP_001372277.1
    NP_001372279.1
    NP_001372280.1
    NP_001372286.1
    NP_001372291.1
    NP_001372308.1
    NP_001372309.1
    NP_001372310.1
    NP_001372311.1
    NP_001372312.1
    NP_001372379.1
    NP_001372381.1
    NP_001372383.1
    NP_001372384.1
    NP_001372386.1
    NP_001372387.1
    NP_001372388.1
    NP_001372389.1
    NP_001372390.1
    NP_003857.2
    XP_011530693.1
    XP_016864286.1
    XP_016864287.1
    XP_024310041.1
    XP_024310042.1
    XP_047272308.1
    XP_047272309.1
    XP_047272310.1
    XP_047272312.1
    XP_047272313.1
    XP_047272314.1
    XP_047272315.1
    XP_047272316.1
    XP_047272317.1
    XP_047272318.1
    XP_047272319.1
    XP_047272321.1
    XP_047272322.1
    XP_047272323.1
    XP_047272324.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101669.3 → NP_001095139.1  inositol polyphosphate 4-phosphatase type II isoform 1

      See identical proteins and their annotated locations for NP_001095139.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC108077, AI198719, BC017924, BC072447, BP360389, BX649090, DA695719
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Related
      ENSP00000262992.4, ENST00000262992.9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    2. NM_001331040.1 → NP_001317969.1  inositol polyphosphate 4-phosphatase type II isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and novel 3' UTR. It encodes isoform 2 which has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC108077, BC072447, BG708971, BX649090, DA695719, DB555643
      Consensus CDS
      CCDS82958.1
      UniProtKB/TrEMBL
      D6RJC3, E7EQN9
      Related
      ENSP00000422793.1, ENST00000509777.5
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    3. NM_001385334.1 → NP_001372263.1  inositol polyphosphate 4-phosphatase type II isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    4. NM_001385335.1 → NP_001372264.1  inositol polyphosphate 4-phosphatase type II isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC093885, AC108060, AC108077, AC139720
      Consensus CDS
      CCDS82958.1
      UniProtKB/TrEMBL
      D6RJC3, E7EQN9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    5. NM_001385336.1 → NP_001372265.1  inositol polyphosphate 4-phosphatase type II isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC093885, AC108060, AC108077, AC138657, AC139720
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    6. NM_001385337.1 → NP_001372266.1  inositol polyphosphate 4-phosphatase type II isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC093885, AC108060, AC108077, AC138657, AC139720
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    7. NM_001385338.1 → NP_001372267.1  inositol polyphosphate 4-phosphatase type II isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    8. NM_001385339.1 → NP_001372268.1  inositol polyphosphate 4-phosphatase type II isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    9. NM_001385340.1 → NP_001372269.1  inositol polyphosphate 4-phosphatase type II isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    10. NM_001385341.1 → NP_001372270.1  inositol polyphosphate 4-phosphatase type II isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    11. NM_001385342.1 → NP_001372271.1  inositol polyphosphate 4-phosphatase type II isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    12. NM_001385343.1 → NP_001372272.1  inositol polyphosphate 4-phosphatase type II isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    13. NM_001385344.1 → NP_001372273.1  inositol polyphosphate 4-phosphatase type II isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    14. NM_001385347.1 → NP_001372276.1  inositol polyphosphate 4-phosphatase type II isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    15. NM_001385348.1 → NP_001372277.1  inositol polyphosphate 4-phosphatase type II isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720
      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    16. NM_001385350.1 → NP_001372279.1  inositol polyphosphate 4-phosphatase type II isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    17. NM_001385351.1 → NP_001372280.1  inositol polyphosphate 4-phosphatase type II isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    18. NM_001385357.1 → NP_001372286.1  inositol polyphosphate 4-phosphatase type II isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    19. NM_001385362.1 → NP_001372291.1  inositol polyphosphate 4-phosphatase type II isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    20. NM_001385379.1 → NP_001372308.1  inositol polyphosphate 4-phosphatase type II isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    21. NM_001385380.1 → NP_001372309.1  inositol polyphosphate 4-phosphatase type II isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    22. NM_001385381.1 → NP_001372310.1  inositol polyphosphate 4-phosphatase type II isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    23. NM_001385382.1 → NP_001372311.1  inositol polyphosphate 4-phosphatase type II isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    24. NM_001385383.1 → NP_001372312.1  inositol polyphosphate 4-phosphatase type II isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    25. NM_001385450.1 → NP_001372379.1  inositol polyphosphate 4-phosphatase type II isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    26. NM_001385452.1 → NP_001372381.1  inositol polyphosphate 4-phosphatase type II isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    27. NM_001385454.1 → NP_001372383.1  inositol polyphosphate 4-phosphatase type II isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    28. NM_001385455.1 → NP_001372384.1  inositol polyphosphate 4-phosphatase type II isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    29. NM_001385457.1 → NP_001372386.1  inositol polyphosphate 4-phosphatase type II isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    30. NM_001385458.1 → NP_001372387.1  inositol polyphosphate 4-phosphatase type II isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    31. NM_001385459.1 → NP_001372388.1  inositol polyphosphate 4-phosphatase type II isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0, E9PCZ3
      Related
      ENSP00000426207.2, ENST00000511838.6

    32. NM_001385460.1 → NP_001372389.1  inositol polyphosphate 4-phosphatase type II isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108077
      UniProtKB/TrEMBL
      E9PHC0
      Related
      ENSP00000421065.1, ENST00000514525.1

    33. NM_001385461.1 → NP_001372390.1  inositol polyphosphate 4-phosphatase type II isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077
      UniProtKB/TrEMBL
      B7Z4Z0

    34. NM_003866.3 → NP_003857.2  inositol polyphosphate 4-phosphatase type II isoform 1

      See identical proteins and their annotated locations for NP_003857.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC108077, AI198719, BC017924, BC072447, BX649090, DA695719
      Consensus CDS
      CCDS3757.1
      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      UniProtKB/TrEMBL
      D6RJC3
      Related
      ENSP00000425487.1, ENST00000513000.5
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    RNA

    1. NR_169599.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    2. NR_169614.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    3. NR_169615.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720

    4. NR_169616.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    5. NR_169617.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077, AC139720

    6. NR_169618.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    7. NR_169619.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    8. NR_169623.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    9. NR_169624.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC093860, AC108060, AC108077

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      142023160..142846535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416359.1 → XP_047272315.1  inositol polyphosphate 4-phosphatase type II isoform X3

      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4

    2. XM_047416356.1 → XP_047272312.1  inositol polyphosphate 4-phosphatase type II isoform X3

      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4

    3. XM_047416357.1 → XP_047272313.1  inositol polyphosphate 4-phosphatase type II isoform X3

      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4

    4. XM_047416358.1 → XP_047272314.1  inositol polyphosphate 4-phosphatase type II isoform X3

      UniProtKB/Swiss-Prot
      O15327, Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4
      Related
      ENSP00000423954.1, ENST00000508116.5

    5. XM_047416362.1 → XP_047272318.1  inositol polyphosphate 4-phosphatase type II isoform X5

    6. XM_047416361.1 → XP_047272317.1  inositol polyphosphate 4-phosphatase type II isoform X5

    7. XM_047416360.1 → XP_047272316.1  inositol polyphosphate 4-phosphatase type II isoform X4

    8. XM_011532391.3 → XP_011530693.1  inositol polyphosphate 4-phosphatase type II isoform X1

      See identical proteins and their annotated locations for XP_011530693.1

      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    9. XM_024454274.2 → XP_024310042.1  inositol polyphosphate 4-phosphatase type II isoform X2

      UniProtKB/TrEMBL
      D6RJC3, E7EQN9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    10. XM_047416354.1 → XP_047272310.1  inositol polyphosphate 4-phosphatase type II isoform X2

      UniProtKB/TrEMBL
      E7EQN9
      Related
      ENSP00000427250.1, ENST00000510812.5

    11. XM_024454273.2 → XP_024310041.1  inositol polyphosphate 4-phosphatase type II isoform X1

      UniProtKB/TrEMBL
      D6RJC3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    12. XM_047416352.1 → XP_047272308.1  inositol polyphosphate 4-phosphatase type II isoform X2

      UniProtKB/TrEMBL
      E7EQN9

    13. XM_047416353.1 → XP_047272309.1  inositol polyphosphate 4-phosphatase type II isoform X2

      UniProtKB/TrEMBL
      E7EQN9

    14. XM_017008797.2 → XP_016864286.1  inositol polyphosphate 4-phosphatase type II isoform X6

      UniProtKB/TrEMBL
      E9PHC0

    15. XM_017008798.2 → XP_016864287.1  inositol polyphosphate 4-phosphatase type II isoform X8

      UniProtKB/TrEMBL
      B7Z4Z0

    16. XM_047416363.1 → XP_047272319.1  inositol polyphosphate 4-phosphatase type II isoform X7

    17. XM_047416365.1 → XP_047272321.1  inositol polyphosphate 4-phosphatase type II isoform X9

    18. XM_047416368.1 → XP_047272324.1  inositol polyphosphate 4-phosphatase type II isoform X11

    19. XM_047416367.1 → XP_047272323.1  inositol polyphosphate 4-phosphatase type II isoform X11

    20. XM_047416366.1 → XP_047272322.1  inositol polyphosphate 4-phosphatase type II isoform X10

    RNA

    1. XR_007057981.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      145340544..146163746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15327.4 GenPept UniProtKB/Swiss-Prot:O15327

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