THORLNC testis associated oncogenic lncRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: THORLNCprovided by HGNC
Official Full Name: testis associated oncogenic lncRNAprovided by HGNC
Primary source: HGNC:HGNC:53788
See related: Ensembl:ENSG00000226856 MIM:619296; AllianceGenome:HGNC:53788
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: THOR
Expression: Restricted expression toward testis (RPKM 7.6) See more
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Genomic context

Location:: 2q14.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (118182922..118186386, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (118616222..118619693, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (118940498..118943962, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
Title: The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
LncRNA THOR promotes endometrial cancer progression through the AKT and ERK signaling pathways.
Title: LncRNA THOR promotes endometrial cancer progression through the AKT and ERK signaling pathways.
Carboxymethylated chitosan alleviated oxidative stress injury in retinal ganglion cells via IncRNA-THOR/IGF2BP1 axis.
Title: Carboxymethylated chitosan alleviated oxidative stress injury in retinal ganglion cells via IncRNA-THOR/IGF2BP1 axis.
Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating beta-Catenin Signaling.
Title: Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating β-Catenin Signaling.
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
Title: A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
Title: Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
THOR mediated IGF2 expression via interacting with IGF2BP1, and affected the downstream MEK-ERK signaling pathway to regulate tongue squamous cell carcinomas cells proliferation.
Title: LncRNA THOR promotes tongue squamous cell carcinomas by stabilizing IGF2BP1 downstream targets.
THOR expression promotes renal cell carcinoma cell growth in vitro and in vivo.
Title: LncRNA THOR promotes human renal cell carcinoma cell growth.
THOR could potentiate the stemness of gastric cancer cells via directly binding to SOX9 3'UTR.
Title: LncRNA THOR increases the stemness of gastric cancer cells via enhancing SOX9 mRNA stability.
lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells by up-regulating c-myc and TGF2BP1 expression.
Title: LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

testis-associated highly-conserved oncogenic long non-coding RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.