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    TAS1R3 taste 1 receptor member 3 [ Homo sapiens (human) ]

    Gene ID: 83756, updated on 17-Jun-2024

    Summary

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    Official Symbol
    TAS1R3provided by HGNC
    Official Full Name
    taste 1 receptor member 3provided by HGNC
    Primary source
    HGNC:HGNC:15661
    See related
    Ensembl:ENSG00000169962 MIM:605865; AllianceGenome:HGNC:15661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1R3
    Summary
    The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAS1R3 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1331280..1335314)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (762865..766905)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1266660..1270694)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 11 Neighboring gene microRNA 6727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1253662-1254352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1254353-1255043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1257229-1257737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1258501-1259010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 59 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 60 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 61 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1281421-1282299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1282501-1283130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1283131-1283760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1288877-1289508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1289509-1290140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1290141-1290771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1291896-1292448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1293036-1293618 Neighboring gene matrix remodeling associated 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3. Shil A, et al. Nutrients, 2020 Jun 22. PMID 32580504, Free PMC Article
    2. Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor. Chéron JB, et al. Chem Senses, 2019 May 29. PMID 30893427, Free PMC Article
    3. Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor. Nakagita T, et al. PLoS One, 2019. PMID 30883570, Free PMC Article
    4. Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium. Lizunkova P, et al. Graefes Arch Clin Exp Ophthalmol, 2019 Jan. PMID 30353220, Free PMC Article
    5. Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer. Tsutsumi R, et al. Laryngoscope, 2016 Mar. PMID 26422579

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in Human Blood Leukocytes.
      Title: Heterodimerization of Chemoreceptors TAS1R3 and mGlu(2) in Human Blood Leukocytes.
    2. Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
      Title: Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
    3. TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.
      Title: TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.
    4. Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
      Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
    5. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
      Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
    6. Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3.
      Title: Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3.
    7. Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
      Title: Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
    8. Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor.
      Title: Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor.
    9. Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
      Title: Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
    10. Using homology modeling, molecular docking and molecular dynamics (MD) simulations, this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3.
      Title: Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sweet taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sweet taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables taste receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sweet taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of umami taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of umami taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of sweet taste receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    taste receptor type 1 member 3
    Names
    sweet taste receptor T1R3
    taste receptor, type 1, member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152228.3 → NP_689414.2  taste receptor type 1 member 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS30556.1
      UniProtKB/Swiss-Prot
      Q5TA49, Q7RTX0, Q8NGW9
      Related
      ENSP00000344411.5, ENST00000339381.6
      Conserved Domains (3) summary
      cd06363
      Location:29 → 488
      PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
      pfam07562
      Location:496 → 547
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd15290
      Location:590 → 819
      7tmC_TAS1R3; type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1331280..1335314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002435.2 → XP_016857924.1  taste receptor type 1 member 3 isoform X1

    2. XM_017002436.2 → XP_016857925.1  taste receptor type 1 member 3 isoform X2

    3. XM_047431571.1 → XP_047287527.1  taste receptor type 1 member 3 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      762865..766905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338994.1 → XP_054194969.1  taste receptor type 1 member 3 isoform X1

    2. XM_054338995.1 → XP_054194970.1  taste receptor type 1 member 3 isoform X2

    3. XM_054338996.1 → XP_054194971.1  taste receptor type 1 member 3 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7RTX0.2 GenPept UniProtKB/Swiss-Prot:Q7RTX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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