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    LCN15 lipocalin 15 [ Homo sapiens (human) ]

    Gene ID: 389812, updated on 17-Jun-2024

    Summary

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    Official Symbol
    LCN15provided by HGNC
    Official Full Name
    lipocalin 15provided by HGNC
    Primary source
    HGNC:HGNC:33777
    See related
    Ensembl:ENSG00000177984 AllianceGenome:HGNC:33777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO6093; UNQ2541
    Summary
    Predicted to enable small molecule binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum (RPKM 4.8), colon (RPKM 2.3) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LCN15 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136759634..136764518, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148992812..148997698, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139654086..139658970, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128593 Neighboring gene lipocalin 6 Neighboring gene microRNA 6722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29324 Neighboring gene lipocalin 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139657693-139658340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29326 Neighboring gene uncharacterized LOC107987143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139665256-139665756 Neighboring gene Sharpr-MPRA regulatory region 7361 Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A proteome-scale map of the SARS-CoV-2-human contactome. Kim DK, et al. Nat Biotechnol, 2023 Jan. PMID 36217029, Free PMC Article
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipocalin-15
    Names
    MSFL2541
    NP_976222.1
    XP_011516974.1
    XP_054218929.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203347.2 → NP_976222.1  lipocalin-15 precursor

      See identical proteins and their annotated locations for NP_976222.1

      Status: VALIDATED

      Source sequence(s)
      AL355987, AY358618
      Consensus CDS
      CCDS7006.1
      UniProtKB/Swiss-Prot
      Q6UWW0
      Related
      ENSP00000313833.5, ENST00000316144.6
      Conserved Domains (1) summary
      pfam00061
      Location:34 → 174
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      136759634..136764518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518672.2 → XP_011516974.1  lipocalin-15 isoform X1

      Conserved Domains (1) summary
      pfam00061
      Location:6 → 131
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      148992812..148997698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362954.1 → XP_054218929.1  lipocalin-15 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWW0.1 GenPept UniProtKB/Swiss-Prot:Q6UWW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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