PF3D7_1031000 ookinete surface protein P25 [Plasmodium falciparum 3D7] - Gene

Summary

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Gene symbol: PF3D7_1031000
Gene description: ookinete surface protein P25
Primary source: PlasmoDB:PF3D7_1031000
Locus tag: PF3D7_1031000
See related: VEuPathDB:PF3D7_1031000
Gene type: protein coding
RNA name: ookinete surface protein P25
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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See PF3D7_1031000 in Genome Data Viewer

Location:: chromosome: 10

Exon count:: 1

Sequence:: Chromosome: 10; NC_037281.1 (1253417..1254070, complement)

Chromosome 10 - NC_037281.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037281.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.
Title: Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.
Data indicate six crystal structures of Plasmodium falciparum Pfs25 protein (Pfs25) in complex with antibodies elicited by immunization.
Title: Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
In northern India, pfs25 showed less diversity and was the most stable among the targeted genes.
Title: Genetic diversity of Plasmodium falciparum merozoite surface protein-1 (block 2), glutamate-rich protein and sexual stage antigen Pfs25 from Chandigarh, North India.
Pfs25 is a promising malaria transmission-blocking vaccine candidate that, along with CtxB, accumulates as a soluble, properly folded and functional protein within algal chloroplasts, and it is stable in freeze-dried alga cells at ambient temperatures.
Title: Alga-produced cholera toxin-Pfs25 fusion proteins as oral vaccines.
3D model of Pfs25; Pfs25 & malaria transmission blocking monoclonal antibody 4B7 scFv docking results indicate EGF domain III of Pfs25 protein interacts with scFv region of modeled 4B7 antibody forming 7 hydrogen bonds
Title: Structure and mechanism of a transmission blocking vaccine candidate protein Pfs25 from P. falciparum: a molecular modeling and docking study.
functional analysis of the 3' gene regulatory elements necessary for the expression of pfs25
Title: 3' gene regulatory elements required for expression of the Plasmodiumfalciparum developmental protein, Pfs25.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by GeneDB

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed