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    PF3D7_1205700 targeted glyoxalase II [ Plasmodium falciparum 3D7 ]

    Gene ID: 811110, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1205700
    Gene description
    targeted glyoxalase II
    Locus tag
    PF3D7_1205700
    See related
    PlasmoDB:PF3D7_1205700; VEuPathDB:PF3D7_1205700
    Gene type
    protein coding
    RNA name
    targeted glyoxalase II
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1205700 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Sequence:
    Chromosome: 12; NC_037284.1 (253155..254123)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein, putative Neighboring gene tetratricopeptide repeat protein, putative Neighboring gene high mobility group protein B3, putative Neighboring gene conserved protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases. Urscher M, et al. Mol Microbiol, 2010 Apr. PMID 20149108
    2. Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts. Akoachere M, et al. Biol Chem, 2005 Jan. PMID 15843146
    3. Compartmentation of redox metabolism in malaria parasites. Kehr S, et al. PLoS Pathog, 2010 Dec 23. PMID 21203490, Free PMC Article
    4. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. Boucher MJ, et al. PLoS Biol, 2018 Sep. PMID 30212465, Free PMC Article
    5. A Prioritized and Validated Resource of Mitochondrial Proteins in Plasmodium Identifies Unique Biology. van Esveld SL, et al. mSphere, 2021 Oct 27. PMID 34494883, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylglyoxal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicoplast HDA PubMed 
    located_in apicoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    targeted glyoxalase II
    XP_001350466.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      253155..254123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350430.1 → XP_001350466.1  targeted glyoxalase II [Plasmodium falciparum 3D7]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V644, A0A024W3V5, A0A024WPH6, A0A024X4R2, A0A0L7KH80, Q71KM2, Q8I5Y8, W4IDD2, W4J3N3, W7FCC6, W7FW07, W7JVP0, W7K2B3
      Conserved Domains (2) summary
      cd07723
      Location:61 → 229
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
      pfam16123
      Location:230 → 319
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    Nucleotide Protein
    Heading Accession and Version

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