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    PF3D7_1342600 myosin A [ Plasmodium falciparum 3D7 ]

    Gene ID: 814200, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1342600
    Gene description
    myosin A
    Locus tag
    PF3D7_1342600
    See related
    PlasmoDB:PF3D7_1342600; VEuPathDB:PF3D7_1342600
    Gene type
    protein coding
    RNA name
    myosin A
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1342600 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Sequence:
    Chromosome: 13; NC_004331.3 (1673699..1676539)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene casein kinase II beta chain Neighboring gene sporozoite protein essential for cell traversal Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC4, putative Neighboring gene phosphoenolpyruvate carboxykinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes. Siden-Kiamos I, et al. Cell Microbiol, 2011 Dec. PMID 21899701
    2. A dibasic motif in the tail of a class XIV apicomplexan myosin is an essential determinant of plasma membrane localization. Hettmann C, et al. Mol Biol Cell, 2000 Apr. PMID 10749937, Free PMC Article
    3. Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism. Robert-Paganin J, et al. Nat Commun, 2019 Jul 23. PMID 31337750, Free PMC Article
    4. Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. Green JL, et al. J Biol Chem, 2017 Oct 27. PMID 28893907, Free PMC Article
    5. Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA. Douse CH, et al. J Biol Chem, 2012 Oct 26. PMID 22932904, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets.
      Title: Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets.
    2. the complex included GAP40, an additional myosin light chain designated essential light chain (ELC), and several other candidate components. This ELC bound the MyoA neck region adjacent to the MTIP-binding site, and both myosin light chains co-located to the glideosome.
      Title: Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
    3. The conserved interactions between MTIP and MyoA may be specifically modulated by post-translational modification.
      Title: Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA.
    4. Report of the key determinants of binding at the MTIP/MyoA interface, and the first structural study on the complex in solution using protein NMR
      Title: Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
    5. crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail
      Title: Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
    6. Results show that MTIP is expressed in Plasmodium falciparum merozoites, localises to the periphery of the cell and is present in a complex with myosin A.
      Title: The MTIP-myosin A complex in blood stage malaria parasites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell motility ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inner membrane pellicle complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in pellicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1673699..1676539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350111.1 → XP_001350147.1  myosin A [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350147.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P90624, Q8IDR3, Q9UAR6
      UniProtKB/TrEMBL
      A0A024X325, W4IBX5, W7FZ25, W7KAK1
      Conserved Domains (1) summary
      PTZ00014
      Location:1 → 818
      PTZ00014; myosin-A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IDR3.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials