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    PF3D7_1434300 Hsp70/Hsp90 organizing protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 811906, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1434300
    Gene description
    Hsp70/Hsp90 organizing protein
    Locus tag
    PF3D7_1434300
    See related
    PlasmoDB:PF3D7_1434300; VEuPathDB:PF3D7_1434300
    Gene type
    protein coding
    RNA name
    Hsp70/Hsp90 organizing protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1434300 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    1
    Sequence:
    Chromosome: 14; NC_037283.1 (1372903..1374597)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase, putative Neighboring gene calmodulin Neighboring gene conserved protein, unknown function Neighboring gene dynein-related AAA-type ATPase, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers. Makumire S, et al. PLoS One, 2020. PMID 32343703, Free PMC Article
    2. Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities. Silva NSM, et al. Biochim Biophys Acta Proteins Proteom, 2020 Jan. PMID 31525467
    3. Characterisation of the Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop). Gitau GW, et al. Cell Stress Chaperones, 2012 Mar. PMID 22005844, Free PMC Article
    4. Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity. Zininga T, et al. PLoS One, 2015. PMID 26267894, Free PMC Article
    5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study characterised the structure of recombinant Hsp70-Hsp90 organizing protein using synchrotron radiation circular dichroism (SRCD) and small-angle X-ray scattering. Structurally it is a monomeric, elongated but folded protein.
      Title: Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers.
    2. PfHop was shown to co-localise with PfHsp70 and PfHsp90 in parasites at the trophozoite stage
      Title: Characterisation of the Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables ATPase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hsp70/Hsp90 organizing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      1372903..1374597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348462.1 → XP_001348498.1  Hsp70/Hsp90 organizing protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348498.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A144A2J9, Q8ILC1
      UniProtKB/TrEMBL
      A0A024V1Q8, A0A024VJK4, A0A024VZ82, A0A024WJD6, A0A024WYS8, A0A0L1I6R2, A0A0L7K562, W4I8A3, W4IVH9, W7F747, W7FPP9, W7J5R5, W7JLY3
      Conserved Domains (5) summary
      PLN03088
      Location:378 → 524
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      TIGR00990
      Location:247 → 479
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:3 → 479
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:378 → 406
      TPR; TPR repeat [structural motif]
      pfam17830
      Location:503 → 557
      STI1; STI1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ILC1.1

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