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    PF3D7_1460400 ubiquitin carboxyl-terminal hydrolase isozyme L3 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812158, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_1460400
    Gene description
    ubiquitin carboxyl-terminal hydrolase isozyme L3
    Primary source
    PlasmoDB:PF3D7_1460400
    Locus tag
    PF3D7_1460400
    See related
    VEuPathDB:PF3D7_1460400
    Gene type
    protein coding
    RNA name
    ubiquitin carboxyl-terminal hydrolase isozyme L3
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_1460400 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Sequence:
    Chromosome: 14; NC_037283.1 (2461321..2463104)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene 60S ribosomal protein L29, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene inner membrane complex sub-compartment protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activity. Bharti H, et al. Sci Rep, 2022 Jan 18. PMID 35042884, Free PMC Article
    2. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. Artavanis-Tsakonas K, et al. J Biol Chem, 2010 Feb 26. PMID 20042598, Free PMC Article
    3. Nedd8 hydrolysis by UCH proteases in Plasmodium parasites. Karpiyevich M, et al. PLoS Pathog, 2019 Oct. PMID 31658303, Free PMC Article
    4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables deNEDDylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein deneddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L3
    XP_001348750.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      2461321..2463104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348714.2 → XP_001348750.2  ubiquitin carboxyl-terminal hydrolase isozyme L3 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348750.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IKM8
      UniProtKB/TrEMBL
      A0A024UZY7, A0A2I0C1G5, W4I950, W7F0M6, W7FMR4
      Conserved Domains (1) summary
      cl08306
      Location:7 → 222
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    Nucleotide Protein
    Heading Accession and Version

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