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    PF3D7_0507500 subtilisin-like protease 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812875, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_0507500
    Gene description
    subtilisin-like protease 1
    Primary source
    PlasmoDB:PF3D7_0507500
    Locus tag
    PF3D7_0507500
    See related
    VEuPathDB:PF3D7_0507500
    Gene type
    protein coding
    RNA name
    subtilisin-like protease 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0507500 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_004326.2 (307490..309556, complement)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene subtilisin-like ookinete protein SOPT Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene protein CAF40, putative Neighboring gene nuclear protein localization protein 4, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. Lidumniece E, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33975947, Free PMC Article
    2. Molecular determinants of binding to the Plasmodium subtilisin-like protease 1. Fulle S, et al. J Chem Inf Model, 2013 Mar 25. PMID 23414065, Free PMC Article
    3. Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease. Silmon de Monerri NC, et al. Infect Immun, 2011 Mar. PMID 21220481, Free PMC Article
    4. Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. Yeoh S, et al. Cell, 2007 Dec 14. PMID 18083098
    5. Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1. Jean L, et al. J Biol Chem, 2003 Aug 1. PMID 12764150

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we performed molecular dynamics simulations in combination free energy calculations using a homology model of PfSUB1
      Title: Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.
    2. Data indicate that cysteine protease SERA6 localizes to the parasitophorous vacuole (PV) where it is precisely cleaved just prior to egress by an essential serine protease PfSUB1.
      Title: Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
    3. Our findings imply multiple roles for PfSUB1 in the parasite life cycle
      Title: Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in exoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in merozoite dense granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    subtilisin-like protease 1
    XP_001351633.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      307490..309556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351597.1 → XP_001351633.1  subtilisin-like protease 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351633.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I0V0, W7K9M0
      UniProtKB/TrEMBL
      A0A024VAK5, A0A8S9VP47, W4IM03
      Conserved Domains (1) summary
      PTZ00262
      Location:1 → 688
      PTZ00262; subtilisin-like protease; Provisional
    Nucleotide Protein
    Heading Accession and Version

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