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    PF3D7_0815900 dihydrolipoyl dehydrogenase, apicoplast [ Plasmodium falciparum 3D7 ]

    Gene ID: 2655265, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0815900
    Gene description
    dihydrolipoyl dehydrogenase, apicoplast
    Locus tag
    PF3D7_0815900
    See related
    PlasmoDB:PF3D7_0815900; VEuPathDB:PF3D7_0815900
    Gene type
    protein coding
    RNA name
    dihydrolipoyl dehydrogenase, apicoplast
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0815900 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    1
    Sequence:
    Chromosome: 8; NC_004329.3 (743505..745505)

    Chromosome 8 - NC_004329.3Genomic Context describing neighboring genes Neighboring gene ubiquitin Neighboring gene vacuolar protein sorting-associated protein 9, putative Neighboring gene ribosome assembly protein RRB1, putative Neighboring gene phosphopantothenoylcysteine decarboxylase, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004329.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and structural characterization of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum. Laine LM, et al. Biosci Rep, 2015 Jan 14. PMID 25387830, Free PMC Article
    2. The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. McMillan PJ, et al. Mol Microbiol, 2005 Jan. PMID 15612914
    3. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. Boucher MJ, et al. PLoS Biol, 2018 Sep. PMID 30212465, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables dihydrolipoyl dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicoplast HDA PubMed 
    located_in apicoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydrolipoyl dehydrogenase, apicoplast
    XP_001349365.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004329.3 Reference assembly

      Range
      743505..745505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349329.1 → XP_001349365.1  dihydrolipoyl dehydrogenase, apicoplast [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349365.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VL44, A0A024W9B6, A0A024WRY7, A0A0L1I6T7, A0A0L7M701, Q8IAZ6, W4IHW3, W7FGR5, W7G042, W7JE02, W7JVD0
      Conserved Domains (1) summary
      PTZ00153
      Location:11 → 666
      PTZ00153; lipoamide dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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