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    PF3D7_0929400 high molecular weight rhoptry protein 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 813569, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0929400
    Gene description
    high molecular weight rhoptry protein 2
    Locus tag
    PF3D7_0929400
    See related
    PlasmoDB:PF3D7_0929400; VEuPathDB:PF3D7_0929400
    Gene type
    protein coding
    RNA name
    high molecular weight rhoptry protein 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0929400 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Sequence:
    Chromosome: 9; NC_004330.2 (1175203..1180762)

    Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene RNA-binding protein, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene G2 protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004330.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a Plasmodium falciparum rhoptry protein. Holder AA, et al. Mol Biochem Parasitol, 1985 Mar. PMID 3887156
    2. Live-Cell FRET Reveals that Malaria Nutrient Channel Proteins CLAG3 and RhopH2 Remain Associated throughout Their Tortuous Trafficking. Ahmad M, et al. mBio, 2020 Sep 8. PMID 32900800, Free PMC Article
    3. RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. falciparum-infected erythrocyte membranes. Pasternak M, et al. Commun Biol, 2022 Apr 7. PMID 35393572, Free PMC Article
    4. Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate. Counihan NA, et al. Elife, 2017 Mar 2. PMID 28252383, Free PMC Article
    5. Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, et al. Cell Microbiol, 2021 Aug. PMID 33774908, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular vesicle HDA PubMed 
    located_in host cell cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in rhoptry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high molecular weight rhoptry protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004330.2 Reference assembly

      Range
      1175203..1180762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002808921.1 → XP_002808967.1  high molecular weight rhoptry protein 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_002808967.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A2I0BSI4, C0H571, Q8I060
      UniProtKB/TrEMBL
      A0A0L0CVZ0, W7JNQ8
    Nucleotide Protein
    Heading Accession and Version

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