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    mt-Cytb cytochrome b, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26192, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mt-Cytbprovided by RGD
    Official Full Name
    cytochrome b, mitochondrialprovided by RGD
    Primary source
    RGD:620081
    See related
    AllianceGenome:RGD:620081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus (strain: BN/SsNHsdMCW)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CYTB
    Summary
    Predicted to enable metal ion binding activity. Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Involved in several processes, including electron transport coupled proton transport; response to cobalamin; and response to glucagon. Located in mitochondrial inner membrane. Part of protein-containing complex. Biomarker of thyrotoxicosis; type 2 diabetes mellitus; and visual epilepsy. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mt-Cytb in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (14136..15278)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (14136..15278)

    Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 5 Neighboring gene NADH dehydrogenase subunit 6 Neighboring gene tRNA-Glu Neighboring gene tRNA-Thr Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sites of inhibition of mitochondrial electron transport by cadmium. Miccadei S, et al. Chem Biol Interact, 1993 Dec. PMID 8269544
    2. Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. Vlessis AA, et al. J Neurochem, 1990 Apr. PMID 2313294
    3. Changes in rat liver cytochromes b, c1, and c and mitochondrial protein in prolonged protein deficiency. Williams JN Jr, et al. J Nutr, 1966 Dec. PMID 5954822
    4. Effect of experimental thyrotoxicosis on oxidative phosphorylation in rat liver, kidney and brain mitochondria. Satav JG, et al. Mol Cell Endocrinol, 1982 Oct. PMID 6215275
    5. Isolation of the cytochrome-bc1 complex from rat-liver mitochondria. Gellerfors P, et al. Eur J Biochem, 1981 Apr. PMID 6263624

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepcidin or enterocyte iron levels may be involved in the regulation of the age-dependent expression in the duodenum.
      Title: Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquinol-cytochrome-c reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to cobalamin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to glucagon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001665.2 Reference assembly

      Range
      14136..15278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_665641.1 cytochrome b (mitochondrion) [Rattus norvegicus]

      See identical proteins and their annotated locations for YP_665641.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P00159
      UniProtKB/TrEMBL
      B0M1Q8, D6NSR7, D6NSR8, F2Q6S5, H2KXA0, Q5UAI7, Q8HIC4
      Conserved Domains (1) summary
      MTH00100
      Location:1 → 379
      CYTB; cytochrome b; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00159.3

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