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    DOCK10 dedicator of cytokinesis 10 [ Homo sapiens (human) ]

    Gene ID: 55619, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DOCK10provided by HGNC
    Official Full Name
    dedicator of cytokinesis 10provided by HGNC
    Primary source
    HGNC:HGNC:23479
    See related
    Ensembl:ENSG00000135905 MIM:611518; AllianceGenome:HGNC:23479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIZ3; DRIP2; Nbla10300
    Summary
    This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
    Expression
    Broad expression in spleen (RPKM 10.3), lymph node (RPKM 9.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DOCK10 in Genome Data Viewer
    Location:
    2q36.2
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (224765090..225042468, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (225247277..225524737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (225629807..225907185, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373910 Neighboring gene uncharacterized LOC105373911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17187 Neighboring gene coiled-coil domain containing 195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17188 Neighboring gene NANOG hESC enhancer GRCh37_chr2:225757327-225757953 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:225799160-225800136 Neighboring gene uncharacterized LOC124906121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12386 Neighboring gene microRNA 4439 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:225965176-225966375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:225968140-225969339 Neighboring gene NANOG hESC enhancer GRCh37_chr2:226182976-226183547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:226331677-226332177 Neighboring gene MPRA-validated peak4058 silencer Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Neighboring gene MPRA-validated peak4060 silencer Neighboring gene MPRA-validated peak4061 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12387 Neighboring gene uncharacterized LOC105373914 Neighboring gene uncharacterized LOC107985992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10. Parrado A. Mol Biol Rep, 2020 Apr. PMID 32112301
    2. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. Yelo E, et al. Mol Immunol, 2008 Jul. PMID 18499258
    3. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. Alcaraz-García MJ, et al. Hum Immunol, 2011 Jul. PMID 21514340
    4. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Gadea G, et al. Curr Biol, 2008 Oct 14. PMID 18835169
    5. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Shin S, et al. Proc Natl Acad Sci U S A, 2019 Feb 19. PMID 30728292, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.
      Title: Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.
    2. we identified the transcription factor FoxO1 as a potential mediator of ERK2-induced EMT, and thus we investigated the mechanism by which ERK2 regulates FoxO1. Additionally, our analysis revealed that ERK2 induced the expression of Dock10, a Rac1/Cdc42 GEF, during EMT
      Title: ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.
    3. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
      Title: Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.
    4. Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation.
      Title: DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
    5. Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells.
      Title: Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of dedicator of cytokinesis 10 (DOCK10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781A1532

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in marginal zone B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 10
    Names
    dopamine receptor interacting protein 2
    zizimin3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034039.1 RefSeqGene

      Range
      5146..282524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290263.2 → NP_001277192.1  dedicator of cytokinesis protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001277192.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2; also known as DOCK10.2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a distinct start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC011739, DB128847, EU236710
      Consensus CDS
      CCDS74661.1
      UniProtKB/Swiss-Prot
      Q96BY6
      Related
      ENSP00000386694.3, ENST00000409592.7
      Conserved Domains (5) summary
      cd08697
      Location:665 → 854
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1690 → 2135
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:176 → 296
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:176 → 283
      PH; PH domain
      pfam11878
      Location:60 → 147
      DUF3398; Domain of unknown function (DUF3398)

    2. NM_001363762.1 → NP_001350691.1  dedicator of cytokinesis protein 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a distinct start codon, compared to variant 1. The resulting protein (isoform 3) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC011739, AC093806
      Consensus CDS
      CCDS86925.1
      UniProtKB/TrEMBL
      A0A2R8YD85
      Related
      ENSP00000493664.1, ENST00000645028.1
      Conserved Domains (4) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2154
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:79 → 166
      DUF3398; Domain of unknown function (DUF3398)

    3. NM_014689.3 → NP_055504.2  dedicator of cytokinesis protein 10 isoform 1

      See identical proteins and their annotated locations for NP_055504.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1; also known as DOCK10.1) encodes isoform 1.
      Source sequence(s)
      AB014594, AC011739, AC017095, CR749492, DN991477, EG328193, EG328223, EG328495, EG328518, EG328531, EG328562
      Consensus CDS
      CCDS46528.1
      UniProtKB/Swiss-Prot
      B3FL70, O75178, Q68DA4, Q96BY6, Q9NW06, Q9NXI8
      Related
      ENSP00000258390.7, ENST00000258390.12
      Conserved Domains (5) summary
      cd08697
      Location:671 → 860
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1696 → 2141
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:182 → 302
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:182 → 289
      PH; PH domain
      pfam11878
      Location:66 → 153
      DUF3398; Domain of unknown function (DUF3398)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      224765090..225042468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444930.1 → XP_047300886.1  dedicator of cytokinesis protein 10 isoform X15

    2. XM_047444929.1 → XP_047300885.1  dedicator of cytokinesis protein 10 isoform X14

    3. XM_047444922.1 → XP_047300878.1  dedicator of cytokinesis protein 10 isoform X7

    4. XM_047444921.1 → XP_047300877.1  dedicator of cytokinesis protein 10 isoform X6

    5. XM_047444918.1 → XP_047300874.1  dedicator of cytokinesis protein 10 isoform X3

    6. XM_047444928.1 → XP_047300884.1  dedicator of cytokinesis protein 10 isoform X13

    7. XM_047444927.1 → XP_047300883.1  dedicator of cytokinesis protein 10 isoform X12

    8. XM_047444926.1 → XP_047300882.1  dedicator of cytokinesis protein 10 isoform X11

    9. XM_047444919.1 → XP_047300875.1  dedicator of cytokinesis protein 10 isoform X4

    10. XM_017004447.2 → XP_016859936.1  dedicator of cytokinesis protein 10 isoform X2

    11. XM_047444925.1 → XP_047300881.1  dedicator of cytokinesis protein 10 isoform X10

    12. XM_047444923.1 → XP_047300879.1  dedicator of cytokinesis protein 10 isoform X8

    13. XM_006712617.5 → XP_006712680.1  dedicator of cytokinesis protein 10 isoform X1

      Conserved Domains (5) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2154
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:195 → 302
      PH; PH domain
      pfam11878
      Location:79 → 166
      DUF3398; Domain of unknown function (DUF3398)

    14. XM_047444932.1 → XP_047300888.1  dedicator of cytokinesis protein 10 isoform X17

    15. XM_047444931.1 → XP_047300887.1  dedicator of cytokinesis protein 10 isoform X16

    16. XM_047444924.1 → XP_047300880.1  dedicator of cytokinesis protein 10 isoform X9

    17. XM_047444920.1 → XP_047300876.1  dedicator of cytokinesis protein 10 isoform X5

    18. XM_047444936.1 → XP_047300892.1  dedicator of cytokinesis protein 10 isoform X21

    19. XM_047444934.1 → XP_047300890.1  dedicator of cytokinesis protein 10 isoform X19

    20. XM_047444933.1 → XP_047300889.1  dedicator of cytokinesis protein 10 isoform X18

    21. XM_047444935.1 → XP_047300891.1  dedicator of cytokinesis protein 10 isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      225247277..225524737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342856.1 → XP_054198831.1  dedicator of cytokinesis protein 10 isoform X15

    2. XM_054342855.1 → XP_054198830.1  dedicator of cytokinesis protein 10 isoform X14

    3. XM_054342848.1 → XP_054198823.1  dedicator of cytokinesis protein 10 isoform X7

    4. XM_054342847.1 → XP_054198822.1  dedicator of cytokinesis protein 10 isoform X6

    5. XM_054342844.1 → XP_054198819.1  dedicator of cytokinesis protein 10 isoform X3

    6. XM_054342854.1 → XP_054198829.1  dedicator of cytokinesis protein 10 isoform X13

    7. XM_054342853.1 → XP_054198828.1  dedicator of cytokinesis protein 10 isoform X12

    8. XM_054342852.1 → XP_054198827.1  dedicator of cytokinesis protein 10 isoform X11

    9. XM_054342845.1 → XP_054198820.1  dedicator of cytokinesis protein 10 isoform X4

    10. XM_054342843.1 → XP_054198818.1  dedicator of cytokinesis protein 10 isoform X2

    11. XM_054342851.1 → XP_054198826.1  dedicator of cytokinesis protein 10 isoform X10

    12. XM_054342849.1 → XP_054198824.1  dedicator of cytokinesis protein 10 isoform X8

    13. XM_054342842.1 → XP_054198817.1  dedicator of cytokinesis protein 10 isoform X1

    14. XM_054342858.1 → XP_054198833.1  dedicator of cytokinesis protein 10 isoform X17

    15. XM_054342857.1 → XP_054198832.1  dedicator of cytokinesis protein 10 isoform X16

    16. XM_054342850.1 → XP_054198825.1  dedicator of cytokinesis protein 10 isoform X9

    17. XM_054342846.1 → XP_054198821.1  dedicator of cytokinesis protein 10 isoform X5

    18. XM_054342862.1 → XP_054198837.1  dedicator of cytokinesis protein 10 isoform X21

    19. XM_054342860.1 → XP_054198835.1  dedicator of cytokinesis protein 10 isoform X19

    20. XM_054342859.1 → XP_054198834.1  dedicator of cytokinesis protein 10 isoform X18

    21. XM_054342861.1 → XP_054198836.1  dedicator of cytokinesis protein 10 isoform X20

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_017718.1: Suppressed sequence

      Description
      NM_017718.1: This RefSeq was permanently suppressed because it is a a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BY6.3 GenPept UniProtKB/Swiss-Prot:Q96BY6

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