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    SHC3 SHC adaptor protein 3 [ Homo sapiens (human) ]

    Gene ID: 53358, updated on 28-Oct-2024

    Summary

    Official Symbol
    SHC3provided by HGNC
    Official Full Name
    SHC adaptor protein 3provided by HGNC
    Primary source
    HGNC:HGNC:18181
    See related
    Ensembl:ENSG00000148082 MIM:605263; AllianceGenome:HGNC:18181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAI; NSHC; SHCC; N-Shc
    Summary
    Enables phosphotyrosine residue binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.7) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SHC3 in Genome Data Viewer
    Location:
    9q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (89005771..89178818, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (101168260..101341598, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91620686..91793733, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91613461-91613962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91613963-91614462 Neighboring gene PEST containing nuclear protein pseudogene 2 Neighboring gene uncharacterized LOC124902206 Neighboring gene sphingosine-1-phosphate receptor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91652935-91653434 Neighboring gene negCOR silencer S5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91788095-91788595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91787594-91788094 Neighboring gene Sharpr-MPRA regulatory region 4063 Neighboring gene uncharacterized LOC105376136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91896966-91897484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28528 Neighboring gene microRNA 3153 Neighboring gene CDC28 protein kinase regulatory subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
    tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ45325, DKFZp686H1544

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SHC-transforming protein 3
    Names
    SH2 domain protein C3
    SHC (Src homology 2 domain containing) transforming protein 3
    SHC-transforming protein C
    Shc3 p51
    neuronal Shc
    protein Rai
    src homology 2 domain-containing transforming protein C3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016848.6NP_058544.3  SHC-transforming protein 3

      See identical proteins and their annotated locations for NP_058544.3

      Status: VALIDATED

      Source sequence(s)
      AL160054, AL353150, AL772202, BC026314, D84361
      Consensus CDS
      CCDS6681.1
      UniProtKB/Swiss-Prot
      Q5T7I7, Q8TAP2, Q92529, Q9UCX5
      Related
      ENSP00000364995.4, ENST00000375835.9
      Conserved Domains (2) summary
      cd09925
      Location:492594
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:139310
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      89005771..89178818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      101168260..101341598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)