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    UCC1 Ucc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850921, updated on 17-May-2024

    Summary

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    Gene symbol
    UCC1
    Gene description
    Ucc1p
    Primary source
    FungiDB:YLR224W
    Locus tag
    YLR224W
    See related
    SGD:S000004214; AllianceGenome:SGD:S000004214; VEuPathDB:YLR224W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and cellular response to methylmercury. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UCC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (586464..587573)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Utp13p Neighboring gene Ifh1p Neighboring gene uncharacterized protein Neighboring gene Bur2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous expression and functional analysis of the F-box protein Ucc1 from other yeast species in Saccharomyces cerevisiae. Nakatsukasa K, et al. J Biosci Bioeng, 2019 Dec. PMID 31253511
    2. Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae. Pandita M, et al. J Biochem Mol Toxicol, 2021 Jul. PMID 33797855
    3. Genome-scale analyses of butanol tolerance in Saccharomyces cerevisiae reveal an essential role of protein degradation. González-Ramos D, et al. Biotechnol Biofuels, 2013 Apr 3. PMID 23552365, Free PMC Article
    4. Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells. Lee JY, et al. FEBS Lett, 2015 Sep 14. PMID 26297823
    5. The Ubiquitin Ligase SCF(Ucc1) Acts as a Metabolic Switch for the Glyoxylate Cycle. Nakatsukasa K, et al. Mol Cell, 2015 Jul 2. PMID 25982115

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae.
      Title: Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ucc1p
    NP_013325.1
    • F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      586464..587573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182111.1 → NP_013325.1  TPA: Ucc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013325.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYM4, Q05947
      UniProtKB/TrEMBL
      B3RHB2, B5VNE3, C8ZDI9, G2WJ53, N1P1D1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05947.1

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